2016
DOI: 10.1080/2162402x.2015.1085147
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Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma

Abstract: B-cell responses are emerging as critical regulators of cancer progression. In this study, we investigated the role of B lymphocytes in the microenvironment of human pancreatic ductal adenocarcinoma (PDAC), in a retrospective consecutive series of 104 PDAC patients and in PDAC preclinical models. Immunohistochemical analysis revealed that B cells occupy two histologically distinct compartments in human PDAC, either scatteringly infiltrating (CD20-TILs), or organized in tertiary lymphoid tissue (CD20-TLT). Only… Show more

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Cited by 184 publications
(217 citation statements)
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“…For plasma cells, this held true for scattered, as well as dense, infiltrates (p=0.045 and p=0.022, respectively), while, for B-cells, the effect was only discernible when so-called TLSs were present (p=0.047). This is in concert with previous findings regarding pancreatic adenocarcinomas where only dense infiltrates and not scattered cells have significant impact on survival times (14), seemingly attributable to a more efficient and active anti-tumorigenic milieu (2). Not only cellular mechanisms mediated through B-and T-lymphocytes but also humoral activity -measured by plasma cell contentseem to have considerable influence on the hosts' inflammatory response to tumor cells.…”
Section: Discussionsupporting
confidence: 75%
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“…For plasma cells, this held true for scattered, as well as dense, infiltrates (p=0.045 and p=0.022, respectively), while, for B-cells, the effect was only discernible when so-called TLSs were present (p=0.047). This is in concert with previous findings regarding pancreatic adenocarcinomas where only dense infiltrates and not scattered cells have significant impact on survival times (14), seemingly attributable to a more efficient and active anti-tumorigenic milieu (2). Not only cellular mechanisms mediated through B-and T-lymphocytes but also humoral activity -measured by plasma cell contentseem to have considerable influence on the hosts' inflammatory response to tumor cells.…”
Section: Discussionsupporting
confidence: 75%
“…High B-cell density is said to be associated with improved outcome in gastric, breast and colorectal cancer (9)(10)(11), as well as squamous cell carcinoma of the tongue (12), melanoma and hepatocellular carcinoma (5,13). The same correlation has been shown for pancreatic adenocarcinomas, though here the impact was only measurable if cells were arranged in the pattern of TLSs (4,14). High proportions of TILs have also been shown to be predictive of response to neoadjuvant therapy in breast cancer patients (15).…”
mentioning
confidence: 64%
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“…107 In these mice, the ENO1 DNA vaccine also induced the formation of intratumoral tertiary lymphoid tissue (TLT) with active germinal centers and correlated with increased recruitment of T-cells. 108 Analysis of human PDA tissues by immunohistochemistry revealed two distinct patterns of B-cell distribution, either as randomly infiltrating cells (CD20-tumor-infiltrating …”
Section: Passive Immunotherapy Combined With Antitumor Vaccinesmentioning
confidence: 99%
“…108 Overall, data on ENO1 vaccination indicate that it is a promising candidate target to design adjuvant therapies to prevent recurrences in resected patients or to prolong the survival of untreatable patients.…”
mentioning
confidence: 99%