Spatial distribution of CD115+ and CD11b+ cells and their temporal activation during oxygen-induced retinopathy in mice

Brockmann, Claudia; Dege, Sabrina; Crespo-Garcia, Sergio; Kociok, Norbert; Brockmann, Tobias; Strauß, Olaf; Joussen, Antonia M.

doi:10.1007/s00417-017-3845-0

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…It is well known that the neovascular response in the OIR model is accompanied by upregulation of inflammatory signals, infiltration of mononuclear phagocytes and activation of resident microglia ( Binet et al, 2020 ; Brockmann et al, 2018 ; Davies et al, 2006 ; Sun et al, 2017 ; Wang et al, 2020 ). This relates to preterm human infants where the risk of ROP is associated with sepsis ( Huang et al, 2019b ) and systemic inflammation ( Lee and Dammann, 2012 ; Sood et al, 2010 ).…”

Section: Role Of Vegfr1 In Retinal Vascular Diseasementioning

confidence: 99%

VEGFR1 signaling in retinal angiogenesis and microinflammation

Uemura

Fruttiger

D’Amore

et al. 2021

Progress in Retinal and Eye Research

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188

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Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A, -B, –C, -D, and placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 and 2 (VEGFR1/2), whereas VEGF-B and PlGF only bind VEGFR1. Although much research has been conducted on VEGFR2 to elucidate its key role in retinal diseases, recent efforts have shown the importance and involvement of VEGFR1 and its family of ligands in angiogenesis, vascular permeability, and microinflammatory cascades within the retina. Expression of VEGFR1 depends on the microenvironment, is differentially regulated under hypoxic and inflammatory conditions, and it has been detected in retinal and choroidal endothelial cells, pericytes, retinal and choroidal mononuclear phagocytes (including microglia), Müller cells, photoreceptor cells, and the retinal pigment epithelium. Whilst the VEGF-A decoy function of VEGFR1 is well established, consequences of its direct signaling are less clear. VEGFR1 activation can affect vascular permeability and induce macrophage and microglia production of proinflammatory and proangiogenic mediators. However the ability of the VEGFR1 ligands (VEGF-A, PlGF, and VEGF-B) to compete against each other for receptor binding and to heterodimerize complicates our understanding of the relative contribution of VEGFR1 signaling alone toward the pathologic processes seen in diabetic retinopathy, retinal vascular occlusions, retinopathy of prematurity, and age-related macular degeneration. Clinically, anti-VEGF drugs have proven transformational in these pathologies and their impact on modulation of VEGFR1 signaling is still an opportunity-rich field for further research.

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Section: Role Of Vegfr1 In Retinal Vascular Diseasementioning

confidence: 99%

VEGFR1 signaling in retinal angiogenesis and microinflammation

Uemura

Fruttiger

D’Amore

et al. 2021

Progress in Retinal and Eye Research

Self Cite

188

View full text Add to dashboard Cite

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“…Statistical analysis was performed by one- way ANOVA (b, d, e) and the two-sided Mann-Whitney test (f, h), *p < 0.05 ◂ significantly reduced number of CD11b+ cells. This may result from a milder phenotype of retinal neovascularization in the early phases of the hypoxic phase due to initial improved revascularization in Vhl MCΔ/Δ retinas, with reduced drive to recruit CD11b+ cells to neovascular sites in OIR [27]. Although not statistically significant, our finding that Vhl MCΔ/Δ retinas tended to have reduced lectin + myeloid cells density in neovascular areas (Fig.…”

Section: Discussionmentioning

confidence: 63%

Stabilization of myeloid-derived HIFs promotes vascular regeneration in retinal ischemia

et al. 2019

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The retinal vasculature is tightly organized in a structure that provides for the high metabolic demand of neurons while minimizing interference with incident light. The adverse impact of retinal vascular insufficiency is mitigated by adaptive vascular regeneration but exacerbated by pathological neovascularization. Aberrant growth of neovessels in the retina is responsible for impairment of sight in common blinding disorders including retinopathy of prematurity, proliferative diabetic retinopathy, and age-related macular degeneration. Myeloid cells are key players in this process, with diverse roles that can either promote or protect against ocular neovascularization. We have previously demonstrated that myeloid-derived VEGF, HIF1, and HIF2 are not essential for pathological retinal neovascularization. Here, however, we show by cell-specific depletion of Vhl in a mouse model of retinal ischemia (oxygen-induced retinopathy, OIR) that myeloid-derived HIFs promote VEGF and bFGF expression and enhance vascular regeneration in association with improved density and organization of the astrocytic network.

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Ocular immune‐related diseases: molecular mechanisms and therapy

Wang,

Gao,

Cao

et al. 2024

MedComm

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Ocular immune‐related diseases, represent a spectrum of conditions driven by immune system dysregulation, include but not limit to uveitis, diabetic retinopathy, age‐related macular degeneration, Graves’ ophthalmopathy, etc. The molecular and cellular mechanisms underlying these diseases are typically dysfunctioned immune responses targeting ocular tissues, resulting in inflammation and tissue damage. Recent advances have further elucidated the pivotal role of different immune responses in the development, progression, as well as management of various ocular immune diseases. However, there is currently a relative lack of connection between the cellular mechanisms and treatments of several immune‐related ocular diseases. In this review, we discuss recent findings related to the immunopathogenesis of above‐mentioned diseases. In particular, we summarize the different types of immune cells, inflammatory mediators, and associated signaling pathways that are involved in the pathophysiology of above‐mentioned ophthalmopathies. Furthermore, we also discuss the future directions of utilizing anti‐inflammatory regime in the management of these diseases. This will facilitate a better understanding of the pathogenesis of immune‐related ocular diseases and provide new insights for future treatment approaches.

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Spatial distribution of CD115+ and CD11b+ cells and their temporal activation during oxygen-induced retinopathy in mice

Cited by 4 publications

References 37 publications

VEGFR1 signaling in retinal angiogenesis and microinflammation

VEGFR1 signaling in retinal angiogenesis and microinflammation

Stabilization of myeloid-derived HIFs promotes vascular regeneration in retinal ischemia

Ocular immune‐related diseases: molecular mechanisms and therapy

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