Spatial Distribution of Edema in the Cat Spinal Cord after Impact Injury

Martinez, Laure; Alderman, John L.; Kagan, Richard S.; Osterholm, Jewell L.

doi:10.1227/00006123-198104000-00008

Cited by 18 publications

(1 citation statement)

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“…Alterations in cord conduction occurs within few minutes after injury [44,150,158] whereas, microcirculatory disturbances and secondary cellular damage is seen several minutes to hours after trauma [44,83,105,106,132,151,[158][159][160][161][162][163][164][165]. This indicates that alterations in the spinal cord conduction are not due to cell necrosis or tissue damage but may be caused by early events leading to the development of spinal cord pathology.…”

Section: Spinal Cord Conduction and Cell Injury Following Scimentioning

confidence: 99%

Pathophysiology of Blood-Spinal Cord Barrier in Traumatic Injury and Repair

Sharma¹

2005

CPD

158

218

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Blood-spinal cord barrier (BSCB) plays an important role in the regulation of the fluid microenvironment of the spinal cord. Trauma to the spinal cord impairs the BSCB permeability to proteins leading to vasogenic edema formation. Several endogenous neurochemical mediators and growth factors contribute to trauma induced BSCB disruption. Studies carried out in our laboratory suggest that those drugs and neurotrophic factors capable to attenuate the BSCB dysfunction following trauma are neuroprotective in nature. Whereas, agents that do not exert any influence on the BSCB disruption failed to reduce cell injury. These observations are in line with the idea that BSCB disruption plays an important role in the pathophysiology of spinal cord injuries. The probable mechanism(s) of trauma induced BSCB dysfunction and its contribution to cell injuries are discussed.

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