Spatial Distribution of Phase Singularities in Ventricular Fibrillation

Valderrábano, Miguel; Chen, Peng Sheng; Lin, Shien Fong

doi:10.1161/01.cir.0000080322.67408.b4

Cited by 67 publications

(85 citation statements)

References 36 publications

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“…Optically recorded voltage signals were spatiotemporally filtered to reduce noise. 4,5 Phase mapping 7 was performed to evaluate the location and evolution of phase singularities (PSs) in VF. For cumulative PS display (ie, a PS map) over long acquisition intervals (typically 600 frames), PSs were identified by an automated PS tracking algorithm.…”

Section: Protocol I (N‫:)52؍‬ With a Single Cameramentioning

confidence: 99%

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Mother Rotors and the Mechanisms of D600-Induced Type 2 Ventricular Fibrillation

Lin

Baher

et al. 2004

Circulation

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Background-Two types of ventricular fibrillation (VF) have been demonstrated in isolated rabbit hearts during D600 infusion. Type 1 VF is characterized by the presence of multiple, wandering wavelets, whereas type 2 VF shows local spatiotemporal periodicity. We hypothesized that a single mother rotor underlies type 2 VF. Methods and Results-One (protocol I) or 2 (protocol II) cameras were used to map the epicardial ventricular activations in Langendorff-perfused rabbit hearts. Multiple episodes of type 2 VF were induced in 22 hearts by high-concentration (Ն2.5 mg/L) D600 (protocol I). During type 2 VF, a single spiral wave (nϭ19) and/or an epicardial breakthrough pattern (nϭ11) was present in 14 hearts. These spiral waves either slowly drifted or intermittently anchored on the papillary muscle (PM) of the left ventricle. Dominant-frequency (DF) analyses showed that the highest local DF was near the PM (12.5Ϯ1.1 Hz). There was an excellent correlation between the highest local DF of these spiral waves and breakthroughs (11.8Ϯ1.7 Hz) and the DF of simultaneously obtained global pseudo-ECG (11.2Ϯ1.8 Hz, rϭ0.97, PϽ0.0001) during type 2 VF. We also successfully reproduced the major features of type 2 VF by using the Luo-Rudy action-potential model in a simulated, 3-dimensional tissue slab, under conditions of reduced excitability and flat action-potential duration restitution. Conclusions-Either a stationary or a slowly drifting mother rotor can result in type 2 VF. Colocalization of the stationary mother rotors with the PM suggests the importance of underlying anatomic structures in mother rotor formation.

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Section: Protocol I (N‫:)52؍‬ With a Single Cameramentioning

confidence: 99%

“…2 However, the nature of this focal source during type 2 VF remains unclear. We [3][4][5] previously demonstrated that the papillary muscle (PM) can serve as a site for anchoring reentry. An anchored stationary scroll wave can have a longer life span and can function as a mother rotor.…”

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confidence: 99%

Mother Rotors and the Mechanisms of D600-Induced Type 2 Ventricular Fibrillation

Lin

Baher

et al. 2004

Circulation

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“…The anatomic heterogeneities, which are naturally present, also facilitate conduction blocks and wavebreaks through the source-sink mismatches. 13 For example, epicardial coronary arteries, 14 papillary muscles, 15 transmural sites with abrupt fiber orientation changes, 16 and increased fibrosis resulting from cardiomyopathy 17 can all serve as sites of wavebreaks. With the more recent appreciation that dynamic factors related to electrical restitution also play a key role in facilitating wavebreak, an updated version of the Multiple Wavelet Hypothesis emphasizes that the synergy between dynamic factors and preexisting tissue heterogeneities are the fundamental cause of wavebreaks perpetuating VF.…”

Section: Multiple Wavelet Hypothesismentioning

confidence: 99%

A Tale of Two Fibrillations

et al. 2003

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“…It was reported that such anatomical obstacles included epicardial vessels, ridges of endocardial trabeculae and papillary muscle insertions 12 . This patient had at least three monomorphic VTs (Figs.…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic ventricular tachycardia originating from Purkinje fiber network of left anterior fascicle

Yokoshiki

Makino

Watanabe

et al. 2010

Journal of Electrocardiology

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A 55-year old woman with recurrent syncope and palpitation experienced polymorphic ventricular tachycardia (VT) and more than three monomorphic VTs with a right bundle branch block configuration, either inferior-, middle-, and superior-axis.During the pleomorphic VT, the diastolic potential (dp) was recorded at the antero-lateral left ventricle. Changes in the QRS morphology were associated with the time between dp and onset of QRS complex (dp-V interval), and prolongation of dp-V interval terminated the VT. In addition, the delayed potentials were seen during sinus rhythm around this area. Delivery of radiofrequency current targeting the delayed potentials abolished all the VTs. Different exits from relatively large area of slow conduction in the left anterior fascicle might have produced the pleomorphic VTs.

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Spatial Distribution of Phase Singularities in Ventricular Fibrillation

Abstract: Background-Multiple excitation wavelets are present during ventricular fibrillation (VF).

Cited by 67 publications

References 36 publications

Mother Rotors and the Mechanisms of D600-Induced Type 2 Ventricular Fibrillation

Mother Rotors and the Mechanisms of D600-Induced Type 2 Ventricular Fibrillation

A Tale of Two Fibrillations

Pleomorphic ventricular tachycardia originating from Purkinje fiber network of left anterior fascicle

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