Spatial distribution of tissue level properties in a human femoral cortical bone

Rohrbach, Daniel; Lakshmanan, S.; Peyrin, Françoise; Langer, Max; Gerisch, Alf; Grimal, Quentin; Laugier, Pascal; Raum, Kay

doi:10.1016/j.jbiomech.2012.06.003

Cited by 49 publications

(33 citation statements)

References 39 publications

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“…In all cross-sections, the Haversian canal alignment was approximately perpendicular to the image plane, as confirmed by the evaluation of transverse sections in each anatomical quadrant (data not shown) (35). In the cross-sectional SAM images, only the axial tissue stiffness coefficient c Ã 33 could be measured.…”

Section: Parameters Derived From Cross-sectionssupporting

confidence: 60%

“…Scanning acoustic microscopy and synchrotron radiation microtomography 50-MHz SAM and SRmCT data of one right human femur (female, 72 years) have been obtained in a previous study (35). The donor has not reported any pre-existing conditions that might have affected bone metabolism.…”

Section: Methodsmentioning

confidence: 99%

“…synchrotron radiation micro-computed tomography (SR-mCT) (28,(33)(34)(35)(36)(37), Raman microscopy (26) and scanning small angle X-ray scattering (SAXS) (36). In addition to the establishment of fundamental relations between composition, structure and resulting elastic function, these studies revealed remarkable regional variations of stiffness (CV up to 45.5%) and porosity (CV ¼ 47.5%) in spite of a fairly invariable tissue mineralization (CV ¼ 1.8%) within the femoral shaft (35), an age-related increase of cortical porosity and stiffening of the cortical tissue matrix, and also significant correlations between shaft and neck tissue stiffness values (R 2 ¼ 0.63) (31). Moreover, these large-scale micro-elastic maps of entire cross-sections obtained by 50-MHz SAM have been used as a direct input for simulations of sound propagation through the femoral neck (14)(15)(16) and for numerical homogenization models (38)(39)(40).…”

Section: Introductionmentioning

confidence: 99%

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Distribution of mesoscale elastic properties and mass density in the human femoral shaft

Rohrbach

Grimal

Варга

et al. 2015

Connective Tissue Research

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Cortical bone properties are determined by tissue composition and structure at several hierarchical length scales. In this study, the spatial distribution of micro- and mesoscale elastic properties within a human femoral shaft has been investigated. Microscale tissue degree of mineralization (DMB), cortical vascular porosity Ct.Po and the average transverse isotropic stiffness tensor C(Micro) of cylindrical-shaped samples (diameter: 4.4 mm, N = 56) were obtained from cortical regions between 20 and 85% of the total femur length and around the periphery (anterior, medial, posterior and lateral quadrants) by means of synchrotron radiation µCT (SRµCT) and 50-MHz scanning acoustic microscopy (SAM). Within each cylinder, the volumetric bone mineral density (vBMD) and the mesoscale stiffness tensor C(Meso) were derived using a numerical homogenization approach. Moreover, microelastic maps of the axial elastic coefficient c33 measured by SAM at distinct cross-sectional locations along the femur were used to construct a 3-D multiscale elastic model of the femoral shaft. Variations of vBMD (6.1%) were much lower than the variations of mesoscale elastic coefficients (11.1-21.3%). The variation of DMB was only a minor predictor for variations of the mesoscale elastic properties (0.05 ≤ R(2) ≤ 0.34). Instead, variations of the mesoscale elastic properties could be explained by variations of cortical porosity and microscale elastic properties. These data were suitable inputs for numerical evaluations and may help to unravel the relations between structure and composition on the elastic function in cortical bone.

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Section: Parameters Derived From Cross-sectionssupporting

confidence: 60%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Distribution of mesoscale elastic properties and mass density in the human femoral shaft

Rohrbach

Grimal

Варга

et al. 2015

Connective Tissue Research

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“…Therefore measurements of microscopic elastic properties of bone have been made with in vitro measurement methods, such as nanoindentation and scanning acoustic microscopy (SAM). [8][9][10][11][12][13] These methods can provide information on the elastic modulus, hardness, and acoustic impedance in small areas of bone. These methods especially provide information originating from the direction perpendicular to the specimen surface.…”

Section: Introductionmentioning

confidence: 99%

Local ultrasonic wave velocities in trabeculae measured by micro-Brillouin scattering

Ryo¹,

Fukui²,

Matsukawa³

2014

The Journal of the Acoustical Society of America

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“…With different anatomical regions of bone undergoing different types of strains it would be a reasonable suggestion to study the effects of osteoporosis on different anatomical regions of bone. One study has shown that there was in fact, a statistically significant variation in bone mineralization between anatomical regions of a cross section of bone [49].…”

Section: Discussionmentioning

confidence: 99%

Effects of Ovariectomy and Anatomical Position on the Compact Bone as Seen in Three Month Summer Ovine Model

Kraft¹

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Effects of Ovariectomy and Anatomical Position on the Compact Bone As Seen In Three MonthSummer Ovine Model Bryan KraftThe purpose of this study is to characterize the compact-bone remodeling response to an ovariectomy model of human postmenopausal osteoporosis. Animal models are a beneficial practice allowing for the evaluation of the effectiveness of medical therapies and devices on diseases. The ovine model was chosen for this study due to its large size, similar bone remodeling to humans, and cost Osteons per mm 2 , and the mean osteon area. Densitometry analysis was also performed using the microradiographs using image analysis and the use of an aluminum step wedge on each microradiograph as a key. Once all of the data was collected a 2-way repeated measures ANOVA statistical analysis was performed on the histomorphometry and densitometry data to evaluate the possible differences seen due to treatment, anatomical sector, and possible interaction of both. For the histomorphometry portion there was a significant variation seen between the caudal sectors of bone in the OVX vs control sheep in both the fraction of remodeled material and the mean osteonal area. There was also a significant variation seen between the caudomedial sectors of bone in the OVX vs control sheep for the average Osteons per mm 2 . For the densitometry analysis it was found that the OVX sheep had significantly lower bone density than the control sheep. This study shows that there are significant changes seen even after only 3 months with depleted estrogen levels and that differences can be seen based on the anatomical sector of the bone. With this information it will be important to take this into consideration when creating future studies using the ovariectomized ewe as an animal model for postmenopausal osteoporosis study.vi ACKNOWLEDGMENTS

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Spatial distribution of tissue level properties in a human femoral cortical bone

Cited by 49 publications

References 39 publications

Distribution of mesoscale elastic properties and mass density in the human femoral shaft

Distribution of mesoscale elastic properties and mass density in the human femoral shaft

Local ultrasonic wave velocities in trabeculae measured by micro-Brillouin scattering

Effects of Ovariectomy and Anatomical Position on the Compact Bone as Seen in Three Month Summer Ovine Model

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