Spatial mapping of the DNA adducts in cancer

Krieger, Kimiko L.; Mann, Elise; Lee, Kevin J.; Bolterstein, Elyse; Jebakumar, Deborah; Ittmann, Michael; Zotto, Valeria L. Dal; Shaban, Mohamed; Sreekumar, Arun; Gassman, Natalie R.

doi:10.1016/j.dnarep.2023.103529

Cited by 5 publications

(1 citation statement)

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“…The application of exposome framework can be seen now not only in cancer studies [ 9 – 11 ] but also in other non-communicable diseases such as cardiovascular disease [ 12 – 14 ] and respiratory disease [ 15 – 17 ]. A study by Juarez et al [ 18 ], used an exposome database containing more than 2000 environmental exposures from natural, built and social environment domains and they observed that exposure to ethylene oxide and ethyl dichloride, particulate matter (PM) 2.5 and cigarette closely associated with lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Understanding exposomes and its relation with cancer risk in Malaysia based on epidemiological evidence: a narrative review

Sharif,

Ooi

2024

Genes and Environ

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The prevalence of cancer is increasing globally, and Malaysia is no exception. The exposome represents a paradigm shift in cancer research, emphasizing the importance of a holistic approach that considers the cumulative effect of diverse exposures encountered throughout life. The exposures include dietary factors, air and water pollutants, occupational hazards, lifestyle choices, infectious agents and social determinants of health. The exposome concept acknowledges that each individual’s cancer risk is shaped by not only their genetic makeup but also their unique life experiences and environmental interactions. This comprehensive review was conducted by systematically searching scientific databases such as PubMed, Scopus and Google Scholar, by using the keywords “exposomes (environmental exposures AND/OR physical exposures AND/OR chemical exposures) AND cancer risk AND Malaysia”, for relevant articles published between 2010 and 2023. Articles addressing the relationship between exposomes and cancer risk in the Malaysian population were critically evaluated and summarized. This review aims to provide an update on the epidemiological evidence linking exposomes with cancer risk in Malaysia. This review will provide an update for current findings and research in Malaysia related to identified exposomes-omics interaction and gap in research area related to the subject matter. Understanding the interplay between complex exposomes and carcinogenesis holds the potential to unveil novel preventive strategies that may be beneficial for public health.

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