2024
DOI: 10.1177/0271678x241261949
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Spatial metabolomics reveals key features of hippocampal lipid changes in rats with postoperative cognitive dysfunction

Zheng Lei,
Jie Wan,
Jing-jing Han
et al.

Abstract: Postoperative cognitive dysfunction (POCD) is a common complication after cardiac surgery. Numerous evidence suggest that dysregulation of lipid metabolism is associated with cognitive impairment; however, its precise role in the development of POCD is still obscure. In this study, we established a cardiopulmonary bypass (CPB) model in rats and employed the Barnes maze to assess cognitive function, selecting POCD rats for subsequent experimentation. Utilizing mass spectrometry imaging, we detected plenty of li… Show more

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