Spatial selective attention and inhibition in schizophrenia patients during acute psychosis and at 4-month follow-up

Park, Sohee; Püschel, Jörg; Sauter, Barbara H; Rentsch, Markus; Hell, Daniel

doi:10.1016/s0006-3223(01)01278-1

Cited by 49 publications

(33 citation statements)

References 29 publications

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“…The finding of a reduced DF in patients with schizophrenia with hallucinations is consistent with previous research showing inhibitory deficits in memory in schizophrenia (Soriano et al, 2008;Waters et al, 2003), as well as in other cognitive domains (Park et al, 2002;Weisbrod et al, 2000). However, our data suggest that this inhibitory impairment does not characterize all patients with schizophrenia, but that subgroups of patients with different specific symptoms may be differentially impaired.…”

Section: Discussionsupporting

confidence: 92%

Intentional inhibition in memory and hallucinations: Directed forgetting and updating.

Soriano

Jiménez

Román³

et al. 2009

Neuropsychology

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Hallucinations have been recently associated with inhibitory deficits in memory. In this study, the authors investigated whether hallucinations were related to difficulties to inhibit irrelevant information from episodic memory (Experiment 1) and working memory (Experiment 2). In Experiment 1, a directed forgetting task was used. This task measures participants' ability to intentionally forget some recently learned material, when instructions indicate that it is no longer relevant. In Experiment 2, an updating task was used. This task requires participants to intentionally suppress irrelevant information from working memory. Results showed that patients with schizophrenia with hallucinations presented inhibitory deficits in the directed forgetting task and an increase in the number of intrusions in the updating task, compared to patients without hallucinations and healthy controls. No correlations were found between indices of inhibition and other general, negative or positive symptoms. These findings support the existence of an association between intentional inhibition in memory and hallucinations, and they suggest that problems to suppress memory representations can underlie hallucinations in schizophrenia.

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Section: Discussionsupporting

confidence: 92%

Intentional inhibition in memory and hallucinations: Directed forgetting and updating.

Soriano

Jiménez

Román³

et al. 2009

Neuropsychology

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“…Fuller, Frith, & Jahanshahi, 2000;Park et al, 1996;Park et al, 2002;Vink, Ramsey, Raemaekers, & Kahn, 2005), specifically in acutely psychotic patients with elevated positive symptoms (Hoenig, Hochrein, Muller, & Wagner, 2002;Park et al, 1996;Park et al, 2002). Furthermore, the level of spatial NP deficit was correlated with greater positive symptom severity in unmedicated acutely psychotic patients (Zimmermann, Stark, Kern, Laiacker, Kirsch, & Waitl, 2006).…”

Section: Review Of the Negative Priming Effect In Schizophrenia And Smentioning

confidence: 92%

“…Furthermore, the level of spatial NP deficit was correlated with greater positive symptom severity in unmedicated acutely psychotic patients (Zimmermann, Stark, Kern, Laiacker, Kirsch, & Waitl, 2006). Park et al, (2002) investigated spatial NP in acutely psychotic schizophrenia patients at hospital admission, and followed them up four months later when their positive and negative symptoms were in partial remission. At baseline, spatial NP was reduced in schizophrenic patients with elevated positive symptoms but at the 4-month follow-up, spatial NP was intact.…”

Section: Review Of the Negative Priming Effect In Schizophrenia And Smentioning

confidence: 99%

“…Fuller et al, 2000;MacQueen et al, 2003;Park et al, 1996;Park et al, 2002;Vink et al, 2005;Zimmermann et al, 2006) but it effects may vary with positive symptom severity and medication. Conclusions, though, are somewhat tentative due to several issues in this empirical literature that make crossstudy comparisons difficult.…”

Section: Review Of the Negative Priming Effect In Schizophrenia And Smentioning

confidence: 99%

“…Negative symptoms include poverty of speech, flat affect, anhedonia and anergia. Acutely psychotic schizophrenic patients with elevated positive symptoms, especially if they are unmedicated show reduced or abolished NP (e.g., Beech, Powell, McWilliam, & Claridge, 1989;Park et al, 1996;Park, Puschel, Sauter, Rentsch, & Hell, 2002), but normal NP is observed in medicated schizophrenic patients with low positive symptoms (Park et al, 1996;Park et al, 2002). Anti-dopaminergic drugs seem to play a key role in treating positive symptoms and restoring inhibition (Beech et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

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Attentional window in schizophrenia and schizotypal personality: Insight from negative priming studies

Minas

Park

2007

Applied and Preventive Psychology

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One of the core deficits that characterizes schizophrenia is an increase in distractibility and disinhibition at all levels of information processing. Patients with schizophrenia seem unable to focus attention on the relevant events while ignoring the irrelevant stimuli. This pattern of behavior is also observed in unmedicated schizotypal individuals who may carry liability for schizophrenia. In this review, we focus on studies of attentional inhibition, as assessed by the negative priming paradigm, to elucidate the relationships among deficits in inhibition, clinical symptoms and medication effects. We then consider models of the etiology of deficits in negative priming in schizophrenia and schizotypal personality. Finally, we discuss the potential power of utilizing hypothesis-driven cognitive paradigms in psychiatric research.

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Overview of Animal Models of Schizophrenia

Powell

Geyer

2007

CP Neuroscience

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Animal models of schizophrenia may increase the understanding of the neurological abnormalities associated with the disorder and aid in the development of rational pharmacological treatments. Rather than attempting to model the entire syndrome of schizophrenia, a more biologically oriented approach to animal models has been to focus on specific symptoms of schizophrenia that are more objectively measured in the clinical population and more directly translatable to animals (e.g., observables or endophenotypes). This overview focuses on behavioral measures that have been investigated in rodent models of schizophrenia with varying degrees of predictive, etiological, and construct validity. Because of the severity of cognitive deficits in schizophrenia and their resistance to current treatments, there is a need to develop animal models specific to the cognitive symptoms of schizophrenia. In light of this need, this overview discusses rodent models of cognition with relevance to the core cognitive deficits observed in schizophrenia.

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Spatial selective attention and inhibition in schizophrenia patients during acute psychosis and at 4-month follow-up

Cited by 49 publications

References 29 publications

Intentional inhibition in memory and hallucinations: Directed forgetting and updating.

Intentional inhibition in memory and hallucinations: Directed forgetting and updating.

Attentional window in schizophrenia and schizotypal personality: Insight from negative priming studies

Overview of Animal Models of Schizophrenia

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