Karachi is the largest port in Pakistan, a key port in the China Pakistan Economic Corridor, and a major port in the Indus River basin. Its advantageous geographical location, vast hinterland, and superior port construction conditions have formed a certain scale effect. In the development process of Karachi Port, there are many problems such as limited spatial resources, prominent conflicts between the port and the city, and crowded collection and distribution channels. Based on the actual situation of Karachi Port, this article combined its development advantages and direction, and utilized the Karachi Port development pattern of "internal optimization, external connectivity, eastern connection, and western expansion" (Karachi Port not only needs waterway development, but also inland development, playing a true role in internal optimization and external connectivity). After adopting the method described in this article, the cargo throughput of Karachi Port was 5106.05 million tons; Kasim Port was 4806.32 million tons, and Gwadar Port was 207.63 million tons. The development mode and concept of this article have certain reference significance for similar ports and cities with prominent contradictions and insufficient collection and distribution capacity.