Mumbai city, the financial capital of India is situated on west coast of intra-plate continental region of Peninsular India (PI), which experienced significant historical earthquakes in recent past. Seismic hazard analysis for safe and economic design of structures is important for Mumbai for earthquake disaster study and mitigation. Hence, in the present study, deterministic seismic hazard analysis (DSHA) for Greater Mumbai region (Lat. 18.875 0 N to 19.325 0 N and Long. 72.825 0 E to 73.125 0 E with grid spacing 0.05 0 ) which includes Mumbai city, Suburban, Thane District and Navi Mumbai is carried out by using seismicity database of earthquake magnitude M w ≥ 3.5 since AD 1594 to 2012. The seismic sources are identified from Seismotectonic Atlas of India within the control region of 300 km radius around Mumbai city (Lat. 18.94 0 N, Long. 72.84 0 E). The epistemic uncertainty involved in estimation of different input parameters is accounted within logic tree framework. Final results in terms of spatial variation of 50 th and 84 th percentile (MCE and SSE) rock level peak horizontal acceleration (PHA) and spectral accelerations (S a ) at short and long periods show high seismic hazards on the southern part of the study region, which can be used for seismic design of structures in Greater Mumbai region.