Spatial versus consumptive competition at polyneuronally innervated neuromuscular junctions

Ribchester, Richard R.; Barry, JA

doi:10.1113/expphysiol.1994.sp003781

Cited by 35 publications

(33 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hebbian competition between axons seems to determine this process [1][2][3][4] . In newborn animals, skeletal muscle fibers are polyinnervated by several motor axons, but at the end of the axonal competition the end plates are innervated by a single axon [2,[5][6][7][8][9][10][11][12] . Various signaling molecules and presynaptic receptors can play a role in axonal competition by allowing the various nerve endings to have a mutual influence on one another and on the postsynaptic muscle cell and the terminal Schwann cell.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Action of Presynaptic Muscarinic Acetylcholine Receptors and Adenosine Receptors in Developmental Axonal Competition at the Neuromuscular Junction

Nadal

García²,

Hurtado³

et al. 2016

Dev Neurosci

View full text Add to dashboard Cite

The development of the nervous system involves the initial overproduction of synapses, which promotes connectivity. Hebbian competition between axons with different activities leads to the loss of roughly half of the overproduced elements and this refines connectivity. We used quantitative immunohistochemistry to investigate, in the postnatal day 7 (P7) to P9 neuromuscular junctions, the involvement of muscarinic receptors (muscarinic acetylcholine autoreceptors and the M₁, M₂, and M₄ subtypes) and adenosine receptors (A₁ and A_2A subtypes) in the control of axonal elimination after the mouse levator auris longus muscle had been exposed to selective antagonists in vivo. In a previous study we analyzed the role of each of the individual receptors. Here we investigate the additive or occlusive effects of their inhibitors and thus the existence of synergistic activity between the receptors. The main results show that the A_2A, M₁, M₄, and A₁ receptors (in this order of ability) delayed axonal elimination at P7. M₄ produces some occlusion of the M₁ pathway and some addition to the A₁ pathway, which suggests that they cooperate. M₂ receptors may modulate (by allowing a permissive action) the other receptors, mainly M₄ and A₁. The continued action of these receptors (now including M₂ but not M₄) finally promotes axonal loss at P9. All 4 receptors (M₂, M₁, A₁, and A_2A, in this order of ability) are necessary. The M₄ receptor (which in itself does not affect axon loss) seems to modulate the other receptors. We found a synergistic action between the M₁, A₁, and A_2A receptors, which show an additive effect, whereas the potent M₂ effect is largely independent of the other receptors (though can be modulated by M₄). At P9, there is a full mutual dependence between the A₁ and A_2A receptors in regulating axon loss. In summary, postnatal axonal elimination is a regulated multireceptor mechanism that involves the cooperation of several muscarinic and adenosine receptor subtypes.

show abstract

Section: Introductionmentioning

confidence: 99%

Synergistic Action of Presynaptic Muscarinic Acetylcholine Receptors and Adenosine Receptors in Developmental Axonal Competition at the Neuromuscular Junction

Nadal

García²,

Hurtado³

et al. 2016

Dev Neurosci

View full text Add to dashboard Cite

show abstract

“…The model by Van Essen et al (1990) and the induced-fit model by Ribchester and Barry (1994), both of the neuromuscular system, can be classified as incorporating a form of competition for space; this is most explicit in the model by Van Essen et al (1990). The resource may be space itself or may be some immobile resource.…”

Section: Interference Competition: Competition For Spacementioning

confidence: 99%

“…By analogy with enzyme-substrate and antigen-antibody binding, Ribchester and Barry (1994) selective adhesion between nerve terminal and muscle endplate. Induced-fit model.…”

Section: Vanmentioning

confidence: 99%

Competition in the development of nerve connections: a review of models

Ooyen

2001

Network: Computation in Neural Systems

View full text Add to dashboard Cite

A model of novelty detection is developed which is based on an oscillatory mechanism of memory formation and information processing. The frequency encoding of the input information and adaptation of natural frequencies of network oscillators to the frequency of the input signal are used as the mechanism of information storage. The resonance amplification of network activity is used as a recognition principle for familiar stimuli. Application of the model to novelty detection in the hippocampus is discussed.

show abstract

“…In newborn animals, skeletal muscle fibers are polyinnervated in the NMJ by several motor axons (Redfern, 1970; Brown et al, 1976; Ribchester and Barry, 1994), but at the end of the competitive interactions between the nerve endings, endplates are innervated by a solitary axon (Benoit and Changeux, 1975; O’Brien et al, 1978; Jansen and Fladby, 1990; Sanes and Lichtman, 1999). This peripheral synapse has long been used as a paradigm for studying the principles of synapse development and function (Keller-Peck et al, 2001; Lanuza et al, 2002; Santafé et al, 2009a; Garcia et al, 2011; Lichtman and Tapia, 2013).…”

Section: Introductionmentioning

confidence: 99%

Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development

Tomàs

García

Lanuza

et al. 2017

Front. Mol. Neurosci.

View full text Add to dashboard Cite

During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly half of the neurons initially produced so connectivity is refined and specificity gained. The skeletal muscle fibers in the newborn neuromuscular junction (NMJ) are polyinnervated but by the end of the competition, 2 weeks later, the NMJ are innervated by only one axon. This peripheral synapse has long been used as a convenient model for synapse development. In the last few years, we have studied transmitter release and the local involvement of the presynaptic muscarinic acetylcholine autoreceptors (mAChR), adenosine autoreceptors (AR) and trophic factor receptors (TFR, for neurotrophins and trophic cytokines) during the development of NMJ and in the adult. This review article brings together previously published data and proposes a molecular background for developmental axonal competition and loss. At the end of the first week postnatal, these receptors modulate transmitter release in the various nerve terminals on polyinnervated NMJ and contribute to axonal competition and synapse elimination.

show abstract

Spatial versus consumptive competition at polyneuronally innervated neuromuscular junctions

Cited by 35 publications

References 148 publications

Synergistic Action of Presynaptic Muscarinic Acetylcholine Receptors and Adenosine Receptors in Developmental Axonal Competition at the Neuromuscular Junction

Synergistic Action of Presynaptic Muscarinic Acetylcholine Receptors and Adenosine Receptors in Developmental Axonal Competition at the Neuromuscular Junction

Competition in the development of nerve connections: a review of models

Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development

Contact Info

Product

Resources

About