Improving the accuracy of large measurement systems consisting of multiple laser trackers and Enhanced Reference System (ERS) points is technically challenging. In practice, standard devices with precise distance limits are often used to improve the registration accuracy of laser trackers. However, these standard devices are expensive and need to be calibrated by the Coordinate Measuring Machine (CMM). In addition, the stability of ERS points can significantly affect registration errors. Therefore, this paper proposes a laser tracker registration method based on ERS point-weighted self-calibration and thermal deformation compensation. First, a self-calibration method for simple standard devices based on multilateration measurements is presented, which only utilizes large measurement systems without additional high-precision measurement instruments. Based on this, a weighted registration optimization algorithm for the registration process of a relocation laser tracker is proposed. Then, the position errors of ERS points caused by temperature changes are calculated and compensated based on the thermal deformation coefficient of large structural components. The compensated ERS points are used for the registration of the laser trackers. Finally, the effectiveness of the proposed method is demonstrated by a field measurement experiment on a large spherical shell. Compared with the most widely used benchmark method, the proposed method reduces the average registration error of all ERS points from 0.103 to 0.02 mm.