Spatially engineering tri-layer nanofiber dressings featuring asymmetric wettability for wound healing

Shi, Tingting; Liu, Yuan; Wang, Donghui; Xia, Dan; Li, Baoe; Xu, Ruodan; Li, Ning; Liang, Chunyong; Chen, Menglin

doi:10.1016/j.nanoms.2024.01.008

Cited by 7 publications

(3 citation statements)

References 50 publications

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“…Electrospinning as an advanced nanofabrication technique is rapidly gaining applications in a wide variety of fields ( Bai et al, 2022 ; Cao et al, 2022 ; Chen et al, 2023a ; Shi et al, 2024b ); its success is attributable to a series of unique properties, such as straightforward, single-step, and flexible fabrication, in addition to the use of an inexpensive apparatus ( Sivan et al, 2022b ; Lv et al, 2024a ; Lv et al, 2024b ). Among these, its flexibility allows conveniently combining electrospinning with many traditional techniques and advanced chemical and physical methods ( Yu and Xu, 2023 ; Yu and Zhou, 2024 ).…”

Section: Resultsmentioning

confidence: 99%

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Mao,

Zhou,

Yan

et al. 2024

Front. Bioeng. Biotechnol.

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Combination therapy with oral administration of several active ingredients is a popular clinical treatment for cancer. However, the traditional method has poor convenience, less safety, and low efficiency for patients. The combination of traditional pharmaceutical techniques and advanced material conversion methods can provide new solutions to this issue. In this research, a new kind of hybrid film was created via coaxial electrospraying, followed by a casting process. The films were composed of Reglan and 5-fluorouracil (5-FU)-loaded cellulose acetate (CA) core-shell particles in a polyvinylpyrrolidone (PVP) film matrix. Microscopic observations of these films demonstrated a solid cross section loaded with core-shell particles. X-ray diffraction and Fourier-transform infrared tests verified that the Reglan and 5-FU loaded in the films showed amorphous states and fine compatibilities with the polymeric matrices, i.e., PVP and CA, respectively. In vitro dissolution tests indicated that the films were able to provide the desired asynchronous dual-drug delivery, fast release of Reglan, and sustained release of 5-FU. The controlled release mechanisms were shown to be an erosion mechanism for Reglan and a typical Fickian diffusion mechanism for 5-FU. The protocols reported herein pioneer a new approach for fabricating biomaterials loaded with multiple drugs, each with its own controlled release behavior, for synergistic cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Mao,

Zhou,

Yan

et al. 2024

Front. Bioeng. Biotechnol.

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“…Among the four fundamental elements in an electrospinning apparatus, fiber collector is another one that is full of innovations besides the structural spinneret (Sheikhi et al, 2023). A wide variety of homemade collectors have been reported in literature for organizing the electrospun nanofibers into the desired macroshapes for a certain application Chen, Mo, et al, 2024), particularly the popular layer-by-layer deposition for functional applications (Shi, Liu, et al, 2024;Shi, Zhang, et al, 2024). Three special examples about the interesting organized formats are included in Figure 3c.…”

Section: The Developments Of Ehda On Creating Shapesmentioning

confidence: 99%

“…For "efficacious, safe and convenient" drug delivery, a series of drug release profiles have been developed (Riaz et al, 2024;Shi, Liu, et al, 2024;Shi, Zhang, et al, 2024;Zhang, Tang, et al, 2024;. According to the drug controlled release rate, drug release can be modified to pulsatile release (or fast release), sustained release (or extended release), biphasic release (typically a fast release followed by a sustained release), oral delayed release by a pH-sensitive polymer to resist stomach acid (Figure 4a).…”

Section: Electrospun Nanofibrous Shapes For Drug Releasementioning

confidence: 99%

Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

Yu,

Gong,

Zhou

et al. 2024

WIREs Nanomed Nanobiotechnol

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The shapes of micro‐ and nano‐products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning and electrospraying, are facile in manipulate their products' shapes. In this review, the shapes generated using EHDA for modifying drug release profiles are reviewed. These shapes include linear nanofibers, round micro‐/nano‐particles, and beads‐on‐a‐string hybrids. They can be further divided into different kinds of sub‐shapes, and can be explored for providing the desired pulsatile release, sustained release, biphasic release, delayed release, and pH‐sensitive release. Additionally, the shapes resulted from the organizations of electrospun nanofibers are discussed for drug delivery, and the shapes and inner structures can be considered together for developing novel drug delivery systems. In future, the shapes and the related shape–performance relationships at nanoscale, besides the size, inner structure and the related structure–performance relationships, would further play their important roles in promoting the further developments of drug delivery field.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Multi-drug loaded electrospinning nanofibers promote healing with less scar formation by remodeling wound microenvironment via modulating TGF-β1/Smads/EN1 signal

Zeng,

Guan,

Yusufu

et al. 2024

Chemical Engineering Journal

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Spatially engineering tri-layer nanofiber dressings featuring asymmetric wettability for wound healing

Cited by 7 publications

References 50 publications

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

Multi-drug loaded electrospinning nanofibers promote healing with less scar formation by remodeling wound microenvironment via modulating TGF-β1/Smads/EN1 signal

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