Spatially Resolved Spectral Imaging by A THz-FEL

Irizawa, Akinori; Fujimoto, Masaki; Kawase, K.; Kato, R.; Fujiwara, H.; Higashiya, A.; Macis, Salvatore; Tomarchio, Luca; Lupi, S.; Marcelli, A.; Suga, S.

doi:10.3390/condmat5020038

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…THz imaging is one of the many challenging and stimulating THz applications. Using the unique characteristics of the FEL, Irizawa et al [38] successfully performed highsensitivity spectral imaging of different materials in the THz and far-infrared (FIR) domain. Due to the intensity and directionality of the ISIR source at Osaka, they collected high-sensitivity transmission imaging of extremely low-transparency materials and threedimensional objects in the 3-6 THz range.…”

Section: Discussionmentioning

confidence: 99%

Terahertz as a Frontier Area for Science and Technology

2021

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Recent theoretical and experimental research is triggering interest to technologies based on radiation in the region from ~0.1 to 20 Terahertz (THz). Today, this region of the electromagnetic (e.m.) spectrum is a frontier area for research in many disciplines. The technological roadmap of the THz radiation considers outdoor and indoor communications, security, drug detection, biometrics, food quality control, agriculture, medicine, semiconductors, and air pollution, and demands high-power and sub-ps compact sources, modern detectors, and new integrated systems. There are still many open questions regarding working at THz frequencies and with THz radiation. In particular, we need to invest in new methodologies and in materials exhibiting the unusual or exotic properties of THz. This book contains original papers dealing with some emerging THz applications, new devices, sources and detectors, and materials with advanced properties for applications in biomedicine, cultural heritage, technology, and space.

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Section: Discussionmentioning

confidence: 99%

Terahertz as a Frontier Area for Science and Technology

2021

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“…Leveraging this advantage, along with the properties of MIR and THz radiation, it can be applied across various fields and applications. Consequently, MIR and THz FELs have found utility in numerous scientific research, industrial, and medical applications, including spectroscopy and imaging [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Characterization of RF System for MIR/THz Free Electron Lasers at Chiang Mai University

Kitisri,

Saisut,

Rimjaem

2024

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The establishment of the mid-infrared and terahertz free-electron laser (MIR/THz FEL) facility is ongoing at the PBP-CMU Electron Linac Laboratory (PCELL) in Chiang Mai University. The facility utilizes an S-band radio-frequency (RF) gun and a linear accelerator (linac) to generate and accelerate electron bunches. These electron bunches are accelerated in the RF gun and the linac using RF pulses with a frequency of 2856 MHz. Measuring the RF properties becomes essential, as the RF pulse information can be utilized to estimate the electron beam properties. To achieve the measurement results, we employed an RF measurement system comprising directional couplers, coaxial cables, attenuators, a crystal detector, and an oscilloscope. Prior to conducting measurements, the crystal detector and RF equipment were calibrated and characterized to ensure precise and reliable results. The electron beam energy estimation using the measured RF power was compared with the measured beam energies. The gun and the linac were operated with an absorbed RF power of 1.52 MW and an input power of 1.92 MW, respectively. The estimated electron beam energies were found to be 2.18 MeV and 15.0 MeV, respectively, closely aligning with the measured beam energies of 2.1 MeV and 14.0 MeV after the gun and linac acceleration. These consistent energy values support the reliability of our RF power measurement system and procedure.

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“…Presently, IR-FELs are open at many synchrotron-radiation facilities all over the world since the optical emission was first observed at a laboratory level more than 50 years ago [ 31 ]. Various original experimental studies using IR-FELs are reported as follows: ablation of biological tissues [ 32 , 33 , 34 ], alteration of biological functions [ 35 , 36 ], degradation of protein–metal complexes [ 37 , 38 ], optical and spectroscopic imaging [ 39 , 40 , 41 ], structural dynamics of biomolecules [ 42 , 43 ], chemical reactions in the gas phase [ 44 , 45 , 46 ], decomposition of biopolymers [ 47 , 48 , 49 ], nonlinear-optical physics [ 50 ], and observation of terahertz radiation [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

Disassembly of Amyloid Fibril with Infrared Free Electron Laser

Kawasaki

Tsukiyama

Nguyen

2023

IJMS

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Amyloid fibril causes serious amyloidosis such as neurodegenerative diseases. The structure is composed of rigid β-sheet stacking conformation which makes it hard to disassemble the fibril state without denaturants. Infrared free electron laser (IR-FEL) is an intense picosecond pulsed laser that is oscillated through a linear accelerator, and the oscillation wavelengths are tunable from 3 μm to 100 μm. Many biological and organic compounds can be structurally altered by the mode-selective vibrational excitations due to the wavelength variability and the high-power oscillation energy (10–50 mJ/cm2). We have found that several different kinds of amyloid fibrils in amino acid sequences were commonly disassembled by the irradiation tuned to amide I (6.1–6.2 μm) where the abundance of β-sheet decreased while that of α-helix increased by the vibrational excitation of amide bonds. In this review, we would like to introduce the IR-FEL oscillation system briefly and describe combination studies of experiments and molecular dynamics simulations on disassembling amyloid fibrils of a short peptide (GNNQQNY) from yeast prion and 11-residue peptide (NFLNCYVSGFH) from β2-microglobulin as representative models. Finally, possible applications of IR-FEL for amyloid research can be proposed as a future outlook.

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Spatially Resolved Spectral Imaging by A THz-FEL

Cited by 8 publications

References 28 publications

Terahertz as a Frontier Area for Science and Technology

Terahertz as a Frontier Area for Science and Technology

Characterization of RF System for MIR/THz Free Electron Lasers at Chiang Mai University

Disassembly of Amyloid Fibril with Infrared Free Electron Laser

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