Spatiotemporal analysis of electrically evoked activity in the chicken optic tectum: a VSDI study

Weigel, Stefan; Luksch, Harald

doi:10.1152/jn.00541.2011

Cited by 8 publications

(18 citation statements)

References 58 publications

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“…The effects of blocking nAChR evoked a disinhibition similar to the effect of GABA A receptor blockade (Weigel & Luksch, ). To conclude whether both results are caused by the same mechanism, we compared the effects of curarine with bicuculline in Fig.…”

Section: Resultsmentioning

confidence: 97%

“…The spatiotemporal activity pattern in the TeO is highly modulated by external input from, for example, the NI that are considered to construct a winner‐takes‐all system by excitatory cholinergic and inhibitory GABAergic feedback (Wang et al ., ). Recently we have shown that the tectal response is controlled by GABAergic inhibition (Weigel & Luksch, ). Here, we tested the influence of cholinergic transmission on the tectal network response by blocking the receptors with the respective antagonists.…”

Section: Resultsmentioning

confidence: 99%

“…Disinhibition caused first an increased lateral spread in the superficial layers followed by enhanced activity in intermediate and deeper layers (see also Weigel & Luksch, ). Thus, likely candidates are horizontal neurons in superficial layer 5 (Hunt & Kunzle, ; Hunt & Brecha, ; Luksch & Golz, ).…”

Section: Discussionmentioning

confidence: 99%

“…The position and boundaries of layers were identified in histological sections (Weigel & Luksch, 2012).…”

Section: Vsdi Data Recording and Analysismentioning

confidence: 99%

“…While many studies have analysed tectal cell types and their modulation from the isthmic system physiologically, little is known about local network activity and its modulation in the tectum. We have recently shown with voltage‐sensitive dye imaging that electrical stimulation of the retinorecipient layers results in a stereotypic response, which is under inhibitory control [S. Weigel & H. Luksch () J. Neurophysiol ., 107 , 640–648]. Here, we analysed the contribution of acetylcholine ( AC h) and the NI to evoked tectal responses using a pharmacological approach in a midbrain slice preparation.…”

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confidence: 99%

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Local cholinergic interneurons modulate GABAergic inhibition in the chicken optic tectum

Weigel

Luksch

2013

Eur J of Neuroscience

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The chicken optic tectum (TeO) and its mammalian counterpart, the superior colliculus, are important sensory integration centers. Multimodal information is represented in a topographic map, which plays a role in spatial attention and orientation movements. The TeO is organised in 15 layers with clear input and output regions, and further interconnected with the isthmic nuclei (NI), which modulate the response in a winner-takes-all fashion. While many studies have analysed tectal cell types and their modulation from the isthmic system physiologically, little is known about local network activity and its modulation in the tectum. We have recently shown with voltage-sensitive dye imaging that electrical stimulation of the retinorecipient layers results in a stereotypic response, which is under inhibitory control [S. Weigel & H. Luksch (2012) J. Neurophysiol., 107, 640-648]. Here, we analysed the contribution of acetylcholine (ACh) and the NI to evoked tectal responses using a pharmacological approach in a midbrain slice preparation. Application of the nicotinic ACh receptor (AChR) antagonist curarine increased the tectal response in amplitude, duration and lateral extent. This effect was similar but less pronounced when γ-aminobutyric acid(A) receptors were blocked, indicating interaction of inhibitory and cholinergic neurons. The muscarinic AChR antagonist atropine did not change the response pattern. Removal of the NI, which are thought to be the major source of cholinergic input to the TeO, reduced the response only slightly and did not result in a disinhibition. Based on the data presented here and the neuroanatomical literature of the avian TeO, we propose a model of the underlying local circuitry.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The position and boundaries of layers were identified in histological sections (Weigel & Luksch, 2012).…”

Section: Vsdi Data Recording and Analysismentioning

confidence: 99%

mentioning

confidence: 99%

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Local cholinergic interneurons modulate GABAergic inhibition in the chicken optic tectum

Weigel

Luksch

2013

Eur J of Neuroscience

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Hybrid voltage sensor imaging of eGFP-F expressing neurons in chicken midbrain slices

Weigel

Flisikowska

Schnieke

et al. 2014

Journal of Neuroscience Methods

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Classification of Spatiotemporal Neural Activity Patterns in Brain Imaging Data

Song

Kang

Lee

et al. 2018

Sci Rep

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Various patterns of neural activity are observed in dynamic cortical imaging data. Such patterns may reflect how neurons communicate using the underlying circuitry to perform appropriate functions; thus it is crucial to investigate the spatiotemporal characteristics of the observed neural activity patterns. In general, however, neural activities are highly nonlinear and complex, so it is a demanding job to analyze them quantitatively or to classify the patterns of observed activities in various types of imaging data. Here, we present our implementation of a novel method that successfully addresses the above issues for precise comparison and classification of neural activity patterns. Based on two-dimensional representations of the geometric structure and temporal evolution of activity patterns, our method successfully classified a number of computer-generated sample patterns created from combinations of various spatial and temporal patterns. In addition, we validated our method with voltage-sensitive dye imaging data of Alzheimer’s disease (AD) model mice. Our analysis algorithm successfully distinguished the activity data of AD mice from that of wild type with significantly higher performance than previously suggested methods. Our result provides a pragmatic solution for precise analysis of spatiotemporal patterns of neural imaging data.

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Spatiotemporal analysis of electrically evoked activity in the chicken optic tectum: a VSDI study

Abstract: Weigel S, Luksch H. Spatiotemporal analysis of electrically evoked activity in the chicken optic tectum: a VSDI study.

Cited by 8 publications

References 58 publications

Local cholinergic interneurons modulate GABAergic inhibition in the chicken optic tectum

Local cholinergic interneurons modulate GABAergic inhibition in the chicken optic tectum

Hybrid voltage sensor imaging of eGFP-F expressing neurons in chicken midbrain slices

Classification of Spatiotemporal Neural Activity Patterns in Brain Imaging Data

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