2013
DOI: 10.1371/journal.pone.0074165
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Spatiotemporal Dynamics and Epistatic Interaction Sites in Dengue Virus Type 1: A Comprehensive Sequence-Based Analysis

Abstract: The continuing threat of dengue fever necessitates a comprehensive characterisation of its epidemiological trends. Phylogenetic and recombination events were reconstructed based on 100 worldwide dengue virus (DENV) type 1 genome sequences with an outgroup (prototypes of DENV2-4). The phylodynamic characteristics and site-specific variation were then analysed using data without the outgroup. Five genotypes (GI-GV) and a ladder-like structure with short terminal branch topology were observed in this study. Appar… Show more

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Cited by 11 publications
(11 citation statements)
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References 61 publications
(76 reference statements)
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“…Previous studies describe recombination among DENV-1 strains (Tolou et al, 2001;Aaskov et al, 2007;Carvalho et al, 2010;Shin et al 2013;Chu et al, 2013), however no evidence of recombination was observed in the analysis of the 48 Brazilian strains in this study.…”
Section: Discussioncontrasting
confidence: 86%
See 1 more Smart Citation
“…Previous studies describe recombination among DENV-1 strains (Tolou et al, 2001;Aaskov et al, 2007;Carvalho et al, 2010;Shin et al 2013;Chu et al, 2013), however no evidence of recombination was observed in the analysis of the 48 Brazilian strains in this study.…”
Section: Discussioncontrasting
confidence: 86%
“…Evidences for DENV-1 recombination have been reported previously (Tolou et al, 2001;dos Santos et al, 2002;Aaskov et al, 2007;Chen et al, 2008;Weaver & Vasilakis, 2009;Carvalho et al, 2010;Shin et al, 2013;Chu et al, 2013).…”
Section: Introductionmentioning
confidence: 66%
“…There were 4 vaccinees with the immunization sequence of DENV4 then DENV1 (DENV4 ¡ DENV1), 4 vaccinees who received DENV4 ¡ DENV2, and 2 who received DENV2 ¡ DENV1 (Table 1). Sera from three patients collected at 1 to 3 months after confirmed secondary DENV1 infection were also studied (46). Pooled sera comprised a mixture of convalescentphase sera from four confirmed dengue patients, described previously (21).…”
Section: Methodsmentioning
confidence: 99%
“…Hard‐to‐predict epistatic interactions should not of course be limited to influenza. They can be expected to shape the antigenic evolution of other pathogens …”
Section: Host Immunity Shapes Pathogen Evolutionmentioning
confidence: 99%
“…They can be expected to shape the antigenic evolution of other pathogens. 54,55 Interactions define a pathogen's immunological phenotype…”
Section: Changing Appearancementioning
confidence: 99%