Flood disasters occur frequently and cause great losses. Improving the resilience of urban flood disasters is of great significance to improving disaster prevention and mitigation in the region. The metropolitan area is the center of regional economic development and the key to strengthening the construction of local resilience. However, there is little research on resilience in the metropolitan area. Taking nine cities in the Zhengzhou metropolitan area as the research object, this paper uses the pressure state response (PSR) model to build the evaluation system of the Zhengzhou metropolitan area’s flood disaster resilience and comprehensively uses the entropy weight method, analytic hierarchy process, kernel density estimation method, and factor contribution model to measure the temporal and spatial evolution characteristics of Zhengzhou metropolitan area’s flood disaster resilience from 2010 to 2022, excavating the development trend of the level of flood disaster resilience of members in the Zhengzhou metropolitan area, and explore the driving factors affecting the resilience of the Zhengzhou metropolitan area’s flood disaster. The results show that (1) from 2010 to 2022, the development trend of flood disaster resilience among the Zhengzhou metropolitan area members has obvious differences, the change of pressure resilience is stable, and the state resilience and response resilience increase as a whole; (2) the results show that the resilience of flood disaster in the Zhengzhou metropolitan area has obvious change characteristics in time and space, and the overall trend is to take Zhengzhou as the core to drive the surrounding members’ upward development; (3) in the driving factor analysis, the number of ordinary colleges and universities and the proportion of public security expenditure in fiscal expenditure are the main influencing factors in the resilience evaluation index. The Zhengzhou metropolitan area is the key area of economic development in Henan Province. The research results provide a reference for improving the resilience level of the Zhengzhou metropolitan area and strengthening the prevention and control of flood disasters.