Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis, and tumor stroma development: A study on embryonic and adult human skin

Sellheyer, Klaus; Krahl, Dieter

doi:10.1016/j.jaad.2009.07.013

Cited by 41 publications

(88 citation statements)

References 61 publications

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“…Nonetheless, in a previous study, although nestin was more highly expressed in melanoma than nevi, this association did not reach statistical significance [9]. However, only the nevus was nestin positive, not the adjacent residential melanocytes within the epidermal basal layer [24]. These results suggest that nestin expression activates migrating melanocytes, not just malignant cells.…”

Section: Discussionmentioning

confidence: 74%

Prognostic significance of nestin in primary malignant melanoma of the oral cavity

Kuk

Won²,

Lee³

et al. 2016

Melanoma Research

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Several studies have examined the correlation between nestin expression and the degree of tumor invasion in cutaneous melanoma. However, no information has been reported on nestin in primary mucosal melanoma of the head and neck. The present study examined the expression and prognostic significance of nestin in patients with primary mucosal melanoma of the oral cavity. Nestin expression was examined immunohistochemically in 39 patients (six oral melanoma in-situ cases and 33 invasive oral melanoma cases) and analyzed for association with disease progression. Age, sex, anatomic site, stage, level of invasion, regional lymph node metastasis, surgical margin involvement, and treatment modality were also analyzed. In the 33 invasive melanoma cases, invasion depth correlated significantly with prognosis in univariate and multivariate analyses. High-intensity nestin staining was observed in 14 of the 33 cases and a high proportion of nestin-positive cells was observed in 16 cases. In stage III oral melanoma cases, nestin expression was not significantly associated with disease progression. However, in stage IV cases, both the intensity and the proportion of nestin expression were significantly associated with disease progression (P=0.022 and 0.005, respectively). In all 33 invasive cases, multivariate analyses showed that both the intensity and the proportion of nestin were significantly associated with a poor prognosis (P=0.014 and 0.009; hazard ratio, 3.59 and 4.05; 95% confidence interval, 1.29-9.98 and 1.42-11.56, respectively). In conclusion, nestin can be a valuable prognostic indicator in the advanced-stage (stage IV) cases of oral mucosal melanoma.

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Section: Discussionmentioning

confidence: 74%

Prognostic significance of nestin in primary malignant melanoma of the oral cavity

Kuk

Won²,

Lee³

et al. 2016

Melanoma Research

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“…Cells in the region of the dermal papilla and lower dermal sheath showed normal reactivity 30,31 with specific antibodies to human nestin (Fig. 2i, j) and human versican (Fig.…”

Section: Resultsmentioning

confidence: 99%

Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis

Li¹,

Thangapazham²,

Jian³

et al. 2011

Nat Commun

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Hamartomas are composed of cells native to an organ but abnormal in number, arrangement, or maturity. In tuberous sclerosis complex (TSC), hamartomas develop in multiple organs due to mutations of TSC1 or TSC2. Here we show that TSC2-null fibroblast-like cells grown from human TSC skin hamartomas induced normal human keratinocytes to form hair follicles and stimulated hamartomatous changes. Follicles were complete with sebaceous glands, hair shafts, and inner and outer root sheaths. TSC2-null cells surrounding the hair bulb expressed markers of the dermal sheath and dermal papilla. Tumour xenografts recapitulated characteristics of TSC skin hamartomas with increased mTORC1 activity, angiogenesis, mononuclear phagocytes, and epidermal proliferation. Treatment with an mTORC1 inhibitor normalized these parameters and reduced the number of tumour cells. These studies indicate that TSC2-null cells are the inciting cells for TSC skin hamartomas, and suggest that studies of hamartomas will provide insights into tissue morphogenesis and regeneration.

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“…The intermediate filament Nestin was initially identified as a marker of neural stem and progenitor cells (Cattaneo and McKay, 1990;Lendahl et al, 1990), but has later been shown also to be expressed in stem/progenitor populations in different adult tissues like for example hair follicles (Li et al, 2003;Sellheyer and Krahl, 2010), skeletal muscle (Birbrair et al, 2011;Day et al, 2007) or pancreatic islets (Zulewski et al, 2001). Therefore, it has been suggested that Nestin expression is associated with a stem/progenitor cell population with multipotent properties and regenerative potential (Wiese et al, 2004).…”

Section: Nestin Expressing Progenitorsmentioning

confidence: 99%

Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?

Steenblock

Celis

Androutsellis-Theotokis

et al. 2017

Molecular and Cellular Endocrinology

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Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis, and tumor stroma development: A study on embryonic and adult human skin

Cited by 41 publications

References 61 publications

Prognostic significance of nestin in primary malignant melanoma of the oral cavity

Prognostic significance of nestin in primary malignant melanoma of the oral cavity

Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis

Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?

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