Assessing the environmental vulnerability of the Plateau is beneficial for a number of reasons, including understanding how the region’s environmental vulnerability developed and was formed, as well as for promoting the region’s green development and protecting the environment. This study has created a national response to pressure management model by integrating traditional management practices with the national response to pressure, and by examining the spatial and temporal characteristics of nature resources in the Plateau from 2000 to 2015. The findings demonstrate that the rate of change in Tibet Plateau’s delicate ecological environment is relatively slow, indicating the necessity for new management strategies to safeguard the natural environment.