Special issue on canine genetics: animal models for human disease and gene therapies, new discoveries for canine inherited diseases, and standards and guidelines for clinical genetic testing for domestic dogs

Shaffer, Lisa G.

doi:10.1007/s00439-019-02025-5

Cited by 14 publications

(10 citation statements)

References 12 publications

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“…A special issue of Human Genetics published in 2019 highlights many recent discoveries regarding monogenic diseases in dogs that have significant implications for human health (Shaffer, 2019). For instance, variants in the TTN gene are known to contribute to cardiomyopathies in humans and a missense mutation in TTN was discovered in Doberman pinscher dogs with diagnosed dilated cardiomyopathy (Meurs et al, 2019).…”

Section: Revitalizing Cells Tissues and Organs In Vivomentioning

confidence: 99%

Gene Editing and Gene Therapy: Entering Uncharted Territory in Veterinary Oncology

Wierson¹,

Abel²,

Siegler³

et al. 2021

Preprint

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With rapid advances in gene editing and gene therapy technologies, the development of genetic, cell, or protein-based cures to disease are no longer the realm of science fiction but that of today’s practice. The impact of these technologies are rapidly bringing them to the veterinary market as both enhanced therapeutics and towards modeling their outcomes for translational application. Simply put, gene editing enables scientists to modify an organism’s DNA a priori through the use of site-specific DNA targeting tools like clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR/Cas9). Gene therapy is a broader definition that encompasses the addition of exogenous genetic materials into specific cells to correct a genetic defect. More precisely, the U.S Food and Drug Administration (FDA) defines gene therapy as “a technique that modifies a person’s genes to treat or cure disease” by either (i) replacing a disease-causing gene with a healthy copy of the gene; (ii) inactivating a disease-causing gene that was not functioning properly; or (iii) introducing a new or modified gene into the body to help treat a disease. In some instances, this can be accomplished through direct transfer of DNA or RNA into target cells of interest or more broadly through gene editing. While gene therapy is possible through the simple addition of genetic information into cells of interest, gene editing allows the genome to be reprogrammed intentionally through the deletion of diseased alleles, reconstitution of wild type sequence, or targeted integration of exogenous DNA to impart new function. Cells can be removed from the body, altered, and reinfused, or edited in vivo. Indeed, manufacturing and production efficiencies in gene editing and gene therapy in the 21st century has brought the therapeutic potential of in vitro and in vivo reprogrammed cells, to the front lines of therapeutic intervention (Brooks et al., 2016). For example, CAR-T cell therapy is revolutionizing hematologic cancer care in humans and is being translated to canines by us and others, and gene therapy trials are ongoing for mitral valve disease in dogs.

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Section: Revitalizing Cells Tissues and Organs In Vivomentioning

confidence: 99%

Gene Editing and Gene Therapy: Entering Uncharted Territory in Veterinary Oncology

Wierson¹,

Abel²,

Siegler³

et al. 2021

Preprint

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“…However, research with germ cells from other animal models within the niche of domestic animals, such as canids, could expand knowledge. The canine model has physiology and genetics similar to the human species [3]. Furthermore, the collection of materials for the study of germ cells can be obtained through canine neutering or spaying in veterinary hospitals.…”

Section: Introductionmentioning

confidence: 99%

Step by Step about Germ Cells Development in Canine

Souza

Pieri

Martins

2021

Animals

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Primordial germ cells (PGCs) have been described as precursors of gametes and provide a connection within generations, passing on the genome to the next generation. Failures in the formation of gametes/germ cells can compromise the maintenance and conservation of species. Most of the studies with PGCs have been carried out in mice, but this species is not always the best study model when transposing this knowledge to humans. Domestic animals, such as canines (canine), have become a valuable translational research model for stem cells and therapy. Furthermore, the study of canine germ cells opens new avenues for veterinary reproduction. In this review, the objective is to provide a comprehensive overview of the current knowledge on canine germ cells. The aspects of canine development and germ cells have been discussed since the origin, specifications, and development of spermatogonial canine were first discussed. Additionally, we discussed and explored some in vitro aspects of canine reproduction with germ cells, such as embryonic germ cells and spermatogonial stem cells.

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“…Dogs and cats not only provide companionship but can serve as important animal models for inherited human diseases and conditions. Since the previous special issue of Human Genetics on canine genetics (Shaffer 2019), about 100 additional variants have been identified in the domestic dog (OMIA: Online Mendelian Inheritance in Animals 2021), bringing the total to nearly 450 variants contributing to diseases and traits. Included for the first time in this special issue on companion animals is the domestic cat and nearly 150 variants have been identified that contribute to diseases and traits in our feline friends.…”

Section: Introductionmentioning

confidence: 99%

Special issue on companion animal genetics: Novel variants discovered in wide variety of diseases in dogs, identification and further characterization of traits in dogs and cats, and the use of microarrays in the detection of aneuploidy in dogs

Special issue on canine genetics: animal models for human disease and gene therapies, new discoveries for canine inherited diseases, and standards and guidelines for clinical genetic testing for domestic dogs

Cited by 14 publications

References 12 publications

Gene Editing and Gene Therapy: Entering Uncharted Territory in Veterinary Oncology

Gene Editing and Gene Therapy: Entering Uncharted Territory in Veterinary Oncology

Step by Step about Germ Cells Development in Canine

Special issue on companion animal genetics: Novel variants discovered in wide variety of diseases in dogs, identification and further characterization of traits in dogs and cats, and the use of microarrays in the detection of aneuploidy in dogs

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