Special Issue Recurrent Pregnancy Loss: Etiology, Diagnosis, and Therapy

Christiansen, Ole Bjarne

doi:10.3390/jcm10215040

Cited by 12 publications

(10 citation statements)

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“…Це дозволить покращити прогноз вагітності, знизити рівень перинатальної патології, що буде мати вагомий медико-соціальний ефект. Christiansen OB(2021) [25]; Torchinov AM(2017) [26]; Khobotna IM (2021) [28]; Garrido-Gimenez C(2015) [17];…”

Section: висновкиunclassified

“…Відомо, що в структурі причин перинатальних втрат одне з провідних місць займають екстрагенітальні захворювання жінки. У 60% жінок екстрагенітальна патологія є причиною акушерських ускладнень, в самовільних викиднів утому числі [17,18,25,26,27,28,29].…”

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Miscarriage: A Modern View

Shargorodska

Melenchuk

2022

Act. Probl. of the Modern Med.

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The aim of this study is to analyze the risk factors of miscarriage in modern medical literature. A number of adverse factors and possible risk factors of miscarriage in women of child-bearing age, the latest issues of diagnosis and prevention were scrutinized. In Ukraine, the studies of genetic and demographic processes conducted in recent years have shown that the socially determined demographic crisis observed in the country is significantly deepening due to reproductive losses, which are manifested in an increase in the frequency of lost pregnancies and the birth of inferior offspring in women with diseases of the reproductive system. The frequency of miscarriage ranges from 10% to 30% and does not show a downward trend. In these conditions, the preservation of each pregnancy is important for the demographic development of Ukraine and a factor of national security. The physiological effect of the reproductive function in women occurs due to the harmonious functioning of hormonal, morphological, and immunological mechanisms. The achievements of molecular genetics in recent years have supported the suggestion that miscarriage is not only a polyetiological, but also a multifactorial condition. The recent molecular genetic studies have brought much to deeper understanding of the aetiology and pathogenesis of miscarriage. The study of genetic factors that can underlay the occurrence of miscarriage is a promising direction for the prevention of reproductive losses. The demographic crisis in Ukraine and the unfavourable situation in the field of reproductive health of the population require the development and implementation of complex approaches to the diagnosis and prevention of miscarriage that needs further in-depth investigation of the problem. A significant number of existing methods for predicting and diagnosing miscarriage indicates that there is currently no highly effective and specific method, and the main disadvantages of existing methods for predicting miscarriage, according to the studied literature sources, are low specificity and laboriousness. Among the important tasks, there will be assessment of the population-level data on pregnancy loss and the development of strategies of its prevention.

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Miscarriage: A Modern View

Shargorodska

Melenchuk

2022

Act. Probl. of the Modern Med.

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“…D u e t o a n i n s u f f i c i e n t u n d e r s t a n d i n g o f t h e pathogenesis of RPL and UI, treatment is challenging. The pathogenesis of RPL and UI is multifactorial, and recurring fetal chromosomal abnormalities, the presence of antiphospholipid antibodies, and clinical thyroid disorders are considered risk factors for RPL and UI (8,9). However, the endometrium is a critical factor in RPL and UI because it receives embryos (10,11).…”

Section: Introductionmentioning

confidence: 99%

Investigation of hub ferroptosis-related genes and the immune landscape in recurrent pregnancy loss and unexplained infertility using bioinformatics analysis

Nong¹,

Liang²,

Fang³

et al. 2023

Ann Transl Med

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Background: Recurrent pregnancy loss (RPL) and unexplained infertility (UI) are common pregnancy disorders that affect women's physical and mental health and lack effective treatment. Endometrial factors are one factor that leads to RPL. The latest research indicates that ferroptosis and immunity are closely related to the normal physiological function of the endometrium and may play a role in the pathogenesis of RPL and UI. Therefore, the present study analyzed the relationship between ferroptosis genes and immune infiltration in RPL and UI. Methods:We downloaded the GSE165004 dataset and analyzed differences in ferroptosis-related genes (FRGs) between RPL and UI patients and healthy controls. Hub differentially expressed ferroptosis-related genes (DE-FRGs) were screened using the LASSO algorithm, the SVM-RFE algorithm and the proteinprotein interaction (PPI) network. Differences in immune infiltration between healthy endometrium and RPL and UI endometrium was analyzed, and the relationship between hub DE-FRGs and immune cell infiltration was examined.Results: We extracted 409 FRGs and identified 36 up-regulated and 32 down-regulated DE-FRGs in RPL and UI. Twenty-one genes were screened using the LASSO regression algorithm, and 17 genes were screened using the SVM-RFE algorithm. We intersected the LASSO genes, SVM-RFE genes and PPI network proteins to obtain 5 hub DE-FRGs. Gene Set Enrichment Analysis (GSEA) functional enrichment analysis results indicated that the cytokine-cytokine receptor interaction signaling pathway was the common pathway for hub DE-FRGs. T follicular helper cells were highly infiltrated in RPL and UI, and M1 and M2 macrophages were highly infiltrated. The expression levels of MAPK1 and RELA positively correlated with T follicular helper cells.Conclusions: Ferroptosis-related genes may disrupt endometrial functions and signaling pathways and lead to the occurrence of RPL and UI.

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“…Chromosomal abnormalities in the woman or her partner, congenital or acquired anatomical factors, endocrinopathies, and antiphospholipid syndrome (APS) should be included in the initial diagnostic work‐up of couples with RM. The investigation of autoimmune and alloimmune factors in RM is not recommended by the ESHRE Guideline despite robust evidence of the association between immune disorders and the risk of pregnancy loss 13,14 …”

Section: Introductionmentioning

confidence: 99%

Obesity and recurrent miscarriage: The interconnections between adipose tissue and the immune system

Gonçalves,

Feitosa,

Cavalcante

et al. 2023

American J Rep Immunol

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Currently, obesity is considered a global public health problem. It is the main risk factor for noncommunicable diseases and reproductive complications, such as recurrent miscarriage (RM). RM affects approximately 1% of couples of reproductive age, and recent studies suggest that its prevalence is increasing. Immunological abnormalities may be responsible for a significant number of cases of unexplained RM. Obesity is recognized as a chronic low‐grade inflammatory condition. The accumulation of fat in obese adipose tissue promotes changes in the local and systemic immune response. Adipokines, exosomes, micro‐RNAs, lipids, and other factors released or secreted by adipose tissue are responsible for the interconnection between obesity and the immune system. Obesity‐induced dysregulation of the innate and acquired immune response is also involved in the immunopathology of pregnancy loss in patients with unexplained RM. Therefore, understanding the communication pathways between maternal adipose tissue and the immune response in women living with obesity and RM is an important objective. Thus, diagnostic tools and new immunomodulatory therapies may be proposed for the management of patients with concurrent obesity and RM.

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Special Issue Recurrent Pregnancy Loss: Etiology, Diagnosis, and Therapy

Abstract: The definition of recurrent pregnancy losses (RPL) varies between guidelines from different national and international scientific societies, but overall, a history of two or more (or alternatively, three or more) confirmed pregnancy losses is required for the diagnosis [...]

Cited by 12 publications

References 10 publications

Miscarriage: A Modern View

Miscarriage: A Modern View

Investigation of hub ferroptosis-related genes and the immune landscape in recurrent pregnancy loss and unexplained infertility using bioinformatics analysis

Obesity and recurrent miscarriage: The interconnections between adipose tissue and the immune system

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