Speciation Analysis of Arsenic Compounds by HPLC-ICP-MS: Application for Human Serum and Urine

Nguyen, Manh Ha; Pham, Tien Duc; Nguyen, Thi Lien Huong; Vu, Anh Hai; Ta, Thi Thao; Tu, Minh Binh; Yen, Nguyen Thi Hong; Chu, Dinh Binh

doi:10.1155/2018/9462019

Cited by 31 publications

(11 citation statements)

References 27 publications

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“…According to the recent literature reviews, it shows that groundwater in these regions is contaminated with As at a high level, exceeding the allowed standard from 8 to 18 times. Therefore, the issue of clean water to ensure hygiene for people in Vietnam is not guaranteed [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Iron Oxide Nanoparticle Functionalized Activated Carbon and Its Applications in Arsenic Adsorption

Phong

Minh

2021

Journal of Analytical Methods in Chemistry

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This work reveals the As(V) adsorption behaviors onto iron oxide (Fe3O4) nanoparticles modified activated carbon (AC), originally developed from biochar (BC), as a green adsorbent denoted by FAC. Since FAC has abundant surface functional groups and a desired porous structure that is favorable for the removal of As(V) in contaminated water, FAC has greatly enhanced the As(V) adsorption capacity of the original BC. Various methods were employed to characterize the FAC characteristics and adsorption mechanism, including pHpzc determination, BET specific surface area, elemental analysis (EA), and scanning electron microscopy (SEM). Results show that the AC surface was successfully modified by iron oxide nanoparticles, enhancing the porosity and specific surface area of original adsorbent. Batch adsorption tests indicated a well-fitted Langmuir model and pseudo-second-order model for As(V) adsorption. Additionally, the highest adsorption capacity (Qmax = 32.57 mg/g) by FAC was higher than previously reported literature reviews. Until now, no article was conducted to research the effect of carbon surface chemistry and texture on As removal from waters. It is required to obtain a rational view of optimal conditions to remove As from contaminated water.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Iron Oxide Nanoparticle Functionalized Activated Carbon and Its Applications in Arsenic Adsorption

Phong

Minh

2021

Journal of Analytical Methods in Chemistry

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“…Arsenic compounds were detected via an arsenic monoxide tracer ( 75 As 16 O + ) by ICP-DRC-QMS employed with oxygen as the reaction gas. The separation of five arsenic species in this work was modified from our previous studies [17, 18]. In brief, five arsenic species were separated on the strong anion-exchange column with gradient of mobile phase, which was described as follows: the concentration of methanol and EDTA in the mobile phase was 5% and 0.05%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Speciation Analysis of Arsenic Compounds by High-Performance Liquid Chromatography in Combination with Inductively Coupled Plasma Dynamic Reaction Cell Quadrupole Mass Spectrometry: Application for Vietnamese Rice Samples

Nguyen

Vu-Thi

et al. 2019

Journal of Analytical Methods in Chemistry

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In this work, high-performance liquid chromatography in combination with inductively coupled plasma dynamic reaction cell quadrupole mass spectrometry was introduced and optimized for speciation analysis of five major arsenic species including arsenobetain (AsB), arsenite (As(III)), monomethylarsonic (MMA), dimethylarsenonic acid (DMA), and arsenate (As(V)) in rice samples. Five arsenic compounds were separated on a Hamilton PRP X100 strong anion-exchange column employed with the mobile phase that is compatible with mass spectrometry, containing ammonium carbonate, methanol, and disodium ethylenediaminetetraacetic acid. Arsenic compounds were detected online by inductively coupled plasma dynamic reaction cell quadrupole mass spectrometry utilizing oxygen as the reaction gas at a flow rate of 0.7 mL·min−1. Five selected arsenic species were baseline separated at the optimum experimental conditions. The excellent LOD and LOQ values of the developed method were achieved in the range of 0.5 to 2.9 μg·kg−1 and 1.7 to 9.6 μg·kg−1 for all species of arsenic, respectively. The ionization effect in plasma during chromatographic gradient elution was systematically investigated by using postcolumn injector. Arsenic compounds in rice samples were extracted by diluted nitric acid at elevated temperature. The extraction efficiency and the interconversion of target compounds during sample preparation were also assessed. The full validation of the developed method was performed by using certified reference material, BRC 211, from European Institute of Reference and Standard for speciation analysis. The recovery of all selected arsenic species was in the range of 70 to 135.5%. The validated method was also applied to analyze rice samples collected from some contaminated rice fields. The results showed that As(III), DMA, and As(V) were found in all rice samples. Average concentration (range) of inorganic arsenic and DMA in all rice samples were 130.3 (65.5–228.1) and 32 (8.2–133.01) μg·kg−1, respectively. However, total concentration of inorganic arsenic in most of investigated rice samples was below the maximum residual level according to US-FDA and European Union standards.

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“…ICP‐MS has been regarded as one of the leading techniques in the field of elemental analysis, focusing on the determination of ultra‐trace levels of metals and metalloids in a large variety of sample types [144–151]. This technique has been also applied to the quantitative measurement of metal‐containing PEGylated pharmaceuticals or nanoparticles [152–160].…”

Section: Bioanalytical Methods For Polyethylene Glycols and Pegylatedmentioning

confidence: 99%

Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals

Zhang

Song

et al. 2020

J of Separation Science

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Polyethylene glycols are synthetic polymers composed of repeating oxyethylene subunits, which have been known for non-toxic, non-immunogenic, non-antigenic, good solubility in water and therefore approved for pharmaceutical applications. Recently, attachment or amalgamation of polyethylene glycols to therapeutic small molecules, peptides, proteins, or nanoparticles has become a mature technology for the sake of improving their pharmacokinetic and pharmacological profiles, also referred to as PEGylation. By comparison, there are only a few PEGylated pharmaceuticals have been registered for further clinical trials and even less was approved for marketing. High failure rate of PEGylated pharmaceuticals in pre-clinical and clinical trials could be majorly attributed to their unclear pharmacokinetic behaviors. Therefore, the in vivo fate of the PEGylated pharmaceuticals for the various routes of administration needs to be thoroughly investigated An accurate in vivo pharmacological study thereof highly depends on the precise detection of polyethylene glycols as well as their fragments in biological matrixes. The goal of this review is to highlight the analytical methods that were developed and applied to evaluate the polyethylene glycols in pharmaceutical ingredients and excipients, which bring us closer to bridging

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Speciation Analysis of Arsenic Compounds by HPLC-ICP-MS: Application for Human Serum and Urine

Cited by 31 publications

References 27 publications

Synthesis of Iron Oxide Nanoparticle Functionalized Activated Carbon and Its Applications in Arsenic Adsorption

Synthesis of Iron Oxide Nanoparticle Functionalized Activated Carbon and Its Applications in Arsenic Adsorption

Speciation Analysis of Arsenic Compounds by High-Performance Liquid Chromatography in Combination with Inductively Coupled Plasma Dynamic Reaction Cell Quadrupole Mass Spectrometry: Application for Vietnamese Rice Samples

Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals

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