Species differences in the negative inotropic effect of acetylcholine and soman in rat, guinea pig, and rabbit hearts

Maxwell, Donald M.; Thomsen, R H; Baskin, Steven I.

doi:10.1016/0742-8413(91)90045-u

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Effects On Cardiovascular and Respiratory Systems And Temper1

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2001

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“…Inhibition of atrial AChE with soman reduced the ECs0 of ACh by threefold in all species, but did not change the maximal inotropic effect of ACh. The authors hypothesized that species differences in the negative inotropic effect of ACh may be due to differences in the coupling between myocardial muscarinic receptors and the ion channels that mediate negative inotropy (Maxwell et al, 1991). Worek et al (1994) observed that atropine treatment was very effective in improving the respiratory function after a dose of 60 ~tg/kg of tabun, but ineffective when tabun was given at a dose of 300 ~tg/kg.…”

Section: Effects On Cardiovascular and Respiratory Systems And Tempermentioning

confidence: 98%