Specific Activation of Platelets from Patients Allergic to &lt;i&gt;Dermatophagoides pteronyssinus&lt;/i&gt; by Synthetic Peptides Derived from the Allergen &lt;i&gt;Der p&lt;/i&gt; I

Cardot, Eric; Pestel, Joël; Callebaut, Ina; Lassalle, Philippe; Tsicopoulos, Anne; Gras‐Masse, Hélène; Capron, Arnaud; Joseph, M.

doi:10.1159/000236175

Cited by 23 publications

(14 citation statements)

References 25 publications

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“…This was a process mediated by IgE because these peptides did not stimulate platelets from healthy subjects or patients not allergic to Der p 1. 52 Furthermore, we have shown platelet chemotaxis to allergens to which patients with asthma are specifically sensitized and not to unrelated allergens. 2 The propagation of the immune response requires cell contact through receptor-ligand pairs between antigen-presenting and effecter cells of the adaptive immune response, such as T cells.…”

Section: Platelet Interactions With Immune Cells and Effects On Allermentioning

confidence: 87%

Role of platelets in allergic airway inflammation

Idzko

Pitchford

Page

2015

Journal of Allergy and Clinical Immunology

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Section: Platelet Interactions With Immune Cells and Effects On Allermentioning

confidence: 87%

Role of platelets in allergic airway inflammation

Idzko

Pitchford

Page

2015

Journal of Allergy and Clinical Immunology

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“…Patients allergic to Dermatophagoides pteronyssinus and exposed to synthetic peptides derived from the allergen Der p1 were shown to have activated platelets. This was a process mediated by IgE, which did not stimulate platelets from healthy subjects or non-Der p1-allergic patients, illustrating the specific activation of platelets to allergic stimuli [55].…”

Section: Platelet Activation By Igementioning

confidence: 90%

Defining a role for platelets in allergic inflammation

Pitchford

2007

Biochemical Society Transactions

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There is now considerable evidence suggesting a role for platelets as inflammatory cells. These actions are distinct from their classically known actions performed during thrombosis and haemostasis, and include the expression of adhesion molecules and contact-dependent activation of leucocytes, the release of a plethora of inflammatory mediators, activation in cells of the adaptive immune response and the ability to migrate and undergo chemotaxis. Chronic asthma is a disease characterized by a mixed inflammatory cell pulmonary infiltrate, AHR (airways hyper-responsiveness) and tissue remodelling. Clinical data from patients suffering from asthma, allergic rhinitis and allergic dermatitis reveal changes in platelet behaviour and function during or after allergen exposure. Furthermore, mouse models of allergic inflammation demonstrate a role for intact platelets in eosinophil and lymphocyte recruitment to the lungs, a mechanism that is P-selectin (platelet selectin)-dependent. Models of chronic inflammation also reveal the participation of platelets in tissue remodelling events whereby platelet depletion was found to be more effective in suppressing airway remodelling processes than the administration of a glucocorticosteroid. This process of destruction and repair to the architecture of airway tissue is therefore perhaps enhanced by platelet activation. Recent evidence demonstrates that platelets can undergo chemotaxis and indicates an ability to migrate through inflamed tissue, where they localize to specific tissue sites. Indeed, platelets have been shown to become activated and recruited to various body compartments in direct response to allergen via IgE and this is suggestive of a link between the innate and adaptive immune responses. Thus these actions may lead to pathophysiological events that alter disease progression, since platelet depletion suppresses AHR in allergic rabbits. Further investigations into the role of platelets in inflammation may be beneficial in the search for future therapeutic targets in the treatment of asthma and allergy.

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“…Patients allergic to Dermatophagoides pteronyssinus (Der p1) and exposed to synthetic peptides derived from the allergen Der p1 were shown to have activated platelets. This was a process mediated by IgE, that did not stimulate platelets from healthy subjects or non-Der p1 allergic patients, illustrating the specific activation of platelets to allergic stimuli (Cardot et al, 1992).…”

Section: Platelet Involvement In Antigen Recognitionmentioning

confidence: 93%

Novel uses for anti‐platelet agents as anti‐inflammatory drugs

Pitchford

2007

British J Pharmacology

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An alteration in the character and function of platelets is manifested in patients with inflammatory diseases, and these alterations have been dissociated from the well‐characterized involvement of platelets in thrombosis and haemostasis. Recent evidence reveals platelet activation is sometimes critical in the development of inflammation. The mechanisms by which platelets participate in inflammation are diverse, and offer numerous opportunities for future drug intervention. There is now acceptance that platelets act as innate inflammatory cells in immune responses, with roles as sentinel cells undergoing surveillance, responding to microbial invasion, orchestrating leukocyte recruitment, and migrating through tissue, causing damage and influencing repair processes in chronic disease. Some of these processes are targeted by drugs that are being developed to target platelet participation in atherosclerosis. The actions of platelets therefore influence the pathogenesis of diverse inflammatory diseases in various body compartments, encompassing parasitic and bacterial infection, allergic inflammation (especially asthma and rhinitis), and non‐atopic inflammatory conditions, for example, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and atherosclerosis. This review will first discuss the evidence for platelet activation in these various inflammatory diseases, and secondly discuss the mechanisms by which this pathogenesis occurs and the various anti‐platelet agents which have been developed to combat platelet activation in atherosclerosis and their potential future use for the treatment of other inflammatory diseases.British Journal of Pharmacology (2007) 152, 987–1002; doi:10.1038/sj.bjp.0707364; published online 2 July 2007

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Specific Activation of Platelets from Patients Allergic to <i>Dermatophagoides pteronyssinus</i> by Synthetic Peptides Derived from the Allergen <i>Der p</i> I

Cited by 23 publications

References 25 publications

Role of platelets in allergic airway inflammation

Role of platelets in allergic airway inflammation

Defining a role for platelets in allergic inflammation

Novel uses for anti‐platelet agents as anti‐inflammatory drugs

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