Specific Binding of Vasoactive Intestinal Peptide Receptor in Cephalic and Caudal Lobes of Anterior Pituitary of Incubating and Laying Hens and Roosters.

Gonzales, Sylvia Mae T.; Kawashima, Mitsuo; Kamiyoshi, Michiharu; Kuwayama, Takehito; Tanaka, Katuhide; Ichinoe, Kenji

doi:10.2141/jpsa.31.300

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…Although only White Legohorn was assessed, results of this study support the observations from VIP binding studies. Gonzales et al [40,41] have suggested that VIPRs may be located mainly in the cephalic lobe of the anterior pituitary gland, and specific VIP binding varies depending on the reproductive stages of the chicken. Thus, more mRNA for VIPR is expected in the incubation phase.…”

Section: Discussionmentioning

confidence: 99%

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Molecular Cloning of Chicken Vasoactive Intestinal Polypeptide Receptor Complementary DNA, Tissue Distribution and Chromosomal Localization1

Kansaku

Shimada

Ohkubo

et al. 2001

Biology of Reproduction

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Chicken vasoactive intestinal polypeptide receptor (VIPR) cDNA was cloned by the reverse transcription-polymerase chain reaction method using primers designed on the basis of other species of VIPR cDNA. The cDNA obtained was sequenced by the dideoxy-mediated chain-termination method. Of the 2227 nucleotides that were sequenced, 84, 855, and 1338 bases represent the 5'-untranslated region (UTR), the 3'-UTR, and the open reading frame that predicts a peptide of 446 amino acids. The cDNA of the chicken VIPR shows 65% and 60% homologies to human cDNA of VIP1 and VIP2 receptors, respectively. The clone had the expected similarity to highly conserved features of the other G protein-coupled receptors (GPCRs) such as six cysteine residues that are functionally important in the VIPR subfamily. In addition, the seven potential membrane-spanning domains characteristic of the family B group III GPCR superfamily and highly conserved motif within the third cellular loop between transmembrane regions 5 and 6. Northern blot hybridization analysis in this study indicated mRNA expression of VIPRs in the various tissues of the chicken. Strong signal was detected in the brain and anterior pituitary gland. High levels of VIPR mRNA in the brain was consistent with VIP-binding experiments and with the function of VIP in the brain as a neuroendocrine factor or neurotransmitter. Expression of VIPR was detected in the anterior pituitary gland of chick embryos. The expression of VIPR mRNA in the chick anterior pituitary gland may indicate a regulatory function of VIP on prolactin (PRL) production or PRL cell proliferation during embryogenesis. Chicken VIPR shows high homology with mammalian type I VIPR but, in some part, possesses similarity of amino acid sequence. Expression of VIPR in various tissues supports diverse functions for VIP in the chicken.

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Section: Discussionmentioning

confidence: 99%

“…In birds, the presence of VIP receptors in the anterior pituitary gland has been indicated in the turkey [39] and the chicken [40,41], and stimulation by VIP increased levels of intracellular cAMP in chicken anterior pituitary cells [23]. These studies suggested that the functional VIPRs may be located in the anterior pituitary gland.…”

Section: Introductionmentioning

confidence: 92%

Molecular Cloning of Chicken Vasoactive Intestinal Polypeptide Receptor Complementary DNA, Tissue Distribution and Chromosomal Localization1

Kansaku

Shimada

Ohkubo

et al. 2001

Biology of Reproduction

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“…Vasoactive intestinal peptide (VIP), a brain-gut peptide, is known to stimulate the release of prolactin from the pituitary gland of the turkey hen both in vivo and in vitro (EL HALAWANI et al, 1990) and from the pituitary gland of the hen in vivo (GONZALES et al, 1994a). We have found the presence of VIP receptor in the membrane fraction of the pituitary gland of the hen (GONZALES et al, 1994a) and the amount of specific binding of the VIP receptor in the cephalic lobe of the anterior pituitary is greater in laying hens than in roosters (GONZALES et al, 1994b).…”

Section: Introductionmentioning

confidence: 65%

Progesterone Increases Pituitary VIP Receptor Binding in Hens.

et al. 1994

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“…It has been suggested that a single VIP receptor is expressed and functions in nonmammalian species [31]. In birds, VIP receptors are present on the surface membranes of the anterior pituitary [32][33][34], the hypothalamus [35], the small intestine, and the granulosa cells [36]. VIP stimulation increases levels of intracellular cAMP in chicken pituitary cells [37] and in the hypothalamus [38].…”

Section: Introductionmentioning

confidence: 99%

Expression of Vasoactive Intestinal Peptide Receptor Messenger RNA in the Hypothalamus and Pituitary Throughout the Turkey Reproductive Cycle1

Chaiseha

Youngren

Halawani

2004

Biology of Reproduction

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Vasoactive intestinal peptide (VIP) has been implicated in the regulation of avian reproductive activity and appears to act at the level of the hypothalamus and pituitary. This in situ hybridization histochemistry study describes the distribution of VIP receptor mRNA expression in the hypothalamus and the pituitary of reproductively active (laying) and quiescent (nonphotostimulated, incubating, and photorefractory) female turkeys and characterizes the differences observed in VIP receptor gene expression. VIP receptor mRNA, while expressed throughout the hypothalamus, was specifically expressed in areas known to contain GnRH-I neurons in the chicken, i.e., the lateral septum, medial preoptic area, anterior hypothalamus, and paraventricular nucleus. Significant differences in VIP receptor mRNA expression between different reproductive states was observed only within the infundibular nuclear complex. VIP receptor mRNA was markedly less in nonphotostimulated and photorefractory hens as compared with laying and incubating hens. The most dense VIP receptor mRNA was found in the anterior pituitary, where it was 2.4- and 3.0-fold greater in laying and incubating hens, respectively, as compared with that in nonphotostimulated ones. Hens that stopped incubating and became photorefractory displayed pituitary VIP receptor mRNA levels similar to those of nonphotostimulated birds. The changes in pituitary VIP receptor mRNA expression were positively correlated with known changes in pituitary prolactin (PRL) mRNA expression and PRL content and release. These findings indicate that the variations in PRL secretion observed across the turkey reproductive cycle are, in part, regulated by changes in VIP receptors at the pituitary level.

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Specific Binding of Vasoactive Intestinal Peptide Receptor in Cephalic and Caudal Lobes of Anterior Pituitary of Incubating and Laying Hens and Roosters.

Cited by 3 publications

References 20 publications

Molecular Cloning of Chicken Vasoactive Intestinal Polypeptide Receptor Complementary DNA, Tissue Distribution and Chromosomal Localization1

Molecular Cloning of Chicken Vasoactive Intestinal Polypeptide Receptor Complementary DNA, Tissue Distribution and Chromosomal Localization1

Progesterone Increases Pituitary VIP Receptor Binding in Hens.

Expression of Vasoactive Intestinal Peptide Receptor Messenger RNA in the Hypothalamus and Pituitary Throughout the Turkey Reproductive Cycle1

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