Specific cytotoxic activity of normal T-lymphocytes coated with multivalent hybrid antibody

Laky, Mariana; Moţa, Gabriela; Gheţie, Victor

doi:10.1016/0161-5890(82)90311-x

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…Thus, the BsAb field was of little interest to drug developers until the advent of modern antibody engineering technologies allowed the production of full-length and fragment BsAb. However, this did not prevent academic investigation of the polyclonal redirection of T cells to induce potent lysis of cells bearing the second specificity by BsAb [6, 7, 9–12]. Initially, this approach was used to circumvent the major histocompatibility complex (MHC) restriction of the T cell receptor and engage a broad subset of endogenous T cells for the eradication of tumor or infected cells.…”

Section: The Rise Of Bispecific Abs and Early T Cell Redirecting Techmentioning

confidence: 99%

Bispecific antibodies and CARs: generalized immunotherapeutics harnessing T cell redirection

Zhukovsky¹,

Morse²,

Maus

2016

Current Opinion in Immunology

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To realize the full potential of cancer immunotherapy, the latest generation immunotherapeutics are designed to harness the potent tumor-killing capacity of T cells. Thus, to mobilize T cells, new optimized bispecific antibody (BsAb) designs, enabling efficient polyclonal redirection of cytotoxic activity through binding to CD3 and a Tumor Associated Antigen (TAA) and refined genetically-modified T cells have recently expanded the arsenal of available options for cancer treatment. This review presents the current understanding of the parameters crucial to the design of optimal T cell redirecting BsAb and chimeric antigen receptor (CAR)-modified T cells. However, there are additional questions that require thorough elucidation. Both modalities will benefit from design changes that may increase the therapeutic window. One such approach could employ the discrimination afforded by multiple TAA to significantly increase selectivity.

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