Specific Destruction of Leydig Cells in Mature Rats after In Vivo Administration of Ethane Dimethyl Sulfonate

Molenaar, R.; Rooij, Dirk G. de; Rommerts, F. F. G.; Reuvers, P. J.; Molen, H. J. van der

doi:10.1095/biolreprod33.5.1213

Cited by 111 publications

(75 citation statements)

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“…A similar permeability response is obtained when hCG is injected together with testicular interstitial fluid into the testes (Veijola & Rajaniemi, 1986). We suggested that a direct interaction of hCG with some component(s) present in IF produces a leucotactic factor(s) (Veijola & Rajaniemi, 1989 (Molenaar et al, 1985;Morris et ., 1986). EDS was synthesized as described by Jackson & Jackson (1984).…”

Section: Introductionsupporting

confidence: 60%

Rat testicular interstitial fluid contains mediators of vasopermeability

Tapanainen¹,

Paloneva²,

Veijola³

et al. 1990

Reproduction

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Section: Introductionsupporting

confidence: 60%

Rat testicular interstitial fluid contains mediators of vasopermeability

Tapanainen¹,

Paloneva²,

Veijola³

et al. 1990

Reproduction

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“…In the event of loss of the adult Leydig cells (14,15), stem cells in both locations are capable of regenerating new Leydig cells (16,(20)(21)(22); Fig. S7A).…”

Section: Lh -+ ----+ ----+ ---Dbcamp--+ ----+ ----+ --22hc ---+ ----+mentioning

confidence: 99%

“…However, when these cells are eliminated from adult testes by treating the rats with ethane dimethanesolfonate (EDS), new, fully functional adult Leydig cells reappear (14,15). In initial efforts to localize the precursor cells, seminiferous tubules were isolated from EDS-treated testes and cultured with luteinizing hormone (LH) (16).…”

mentioning

confidence: 99%

Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes

Wang

Jiang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

126

197

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Testicular Leydig cells are the primary source of testosterone in males. Adult Leydig cells have been shown to arise from stem cells present in the neonatal testis. Once established, adult Leydig cells turn over only slowly during adult life, but when these cells are eliminated experimentally from the adult testis, new Leydig cells rapidly reappear. As in the neonatal testis, stem cells in the adult testis are presumed to be the source of the new Leydig cells. As yet, the mechanisms involved in regulating the proliferation and differentiation of these stem cells remain unknown. We developed a unique in vitro system of cultured seminiferous tubules to assess the ability of factors from the seminiferous tubules to regulate the proliferation of the tubule-associated stem cells, and their subsequent entry into the Leydig cell lineage. The proliferation of the stem Leydig cells was stimulated by paracrine factors including Desert hedgehog (DHH), basic fibroblast growth factor (FGF2), platelet-derived growth factor (PDGF), and activin. Suppression of proliferation occurred with transforming growth factor β (TGF-β). The differentiation of the stem cells was regulated positively by DHH, lithium- induced signaling, and activin, and negatively by TGF-β, PDGFBB, and FGF2. DHH functioned as a commitment factor, inducing the transition of stem cells to the progenitor stage and thus into the Leydig cell lineage. Additionally, CD90 (Thy1) was found to be a unique stem cell surface marker that was used to obtain purified stem cells by flow cytometry.

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“…40, No. 6S, 2012 LESIONS OF THE MALE REPRODUCTIVE SYSTEM 49S atrophy of the male mammary gland (Creasy 2008 (Bartlett, Kerr, and Sharpe 1986;Jackson et al 1986;Molenaar et al 1985). response.…”

Section: Degenerationmentioning

confidence: 99%

Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

Creasy

Bube

Rijk³

et al. 2012

Toxicol Pathol

206

198

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the male reproductive system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the Internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the male reproductive system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Specific Destruction of Leydig Cells in Mature Rats after In Vivo Administration of Ethane Dimethyl Sulfonate

Cited by 111 publications

References 0 publications

Rat testicular interstitial fluid contains mediators of vasopermeability

Rat testicular interstitial fluid contains mediators of vasopermeability

Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes

Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

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