2008
DOI: 10.1364/oe.16.015949
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Specific detection of proteins using photonic crystal waveguides

Abstract: Specific detection of proteins is demonstrated using planar photonic crystal waveguides. Using immobilized biotin as probe, streptavidin was captured, causing the waveguide mode cut-off to red-shift. The device was shown to detect a 2.5 nm streptavidin film with a 0.86 nm cut-off red-shift. An improved photonic crystal waveguide sensor design is also described and shown to have a 40% improved bulk refractive index response.

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Cited by 83 publications
(53 citation statements)
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“…The sensitivity of the PCW slab sensor with smaller holes in the line-defect is reported to be 120 nm/RIU after immersing the structure to deionized water [20]. In this study, by in ltrating only the central row of holes, the sensitivity parameter has reached to 282.4 nm/RIU.…”
Section: Sensing Characteristics For Optimized Central Row Of Holesmentioning
confidence: 60%
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“…The sensitivity of the PCW slab sensor with smaller holes in the line-defect is reported to be 120 nm/RIU after immersing the structure to deionized water [20]. In this study, by in ltrating only the central row of holes, the sensitivity parameter has reached to 282.4 nm/RIU.…”
Section: Sensing Characteristics For Optimized Central Row Of Holesmentioning
confidence: 60%
“…Buswell et al enhanced the bulk index sensitivity 40% (from 88 nm/RIU to 120 nm/RIU) by placing small size holes in the line--defect [20]. In this study, a much higher improvement of sensitivity (5.3 times) is achieved by selectively in ltrating only the holes in the line-defect (central holes).…”
Section: Introductionmentioning
confidence: 67%
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“…In medical science, it is becoming more and more popular for bio-photonics [21] and neurophotonics [22]. It is also used in the fields of cancer cell detection, HIV viral load detection [23], protein detection [24], diabetics detection [25], etc. Different types of PCF are used for numerous applications for their superb guiding capability.…”
Section: Introductionmentioning
confidence: 99%
“…In the literature, PC/PCRR (photonic crystal ring resonator) based sensors were reported for chemical sensing, force and strain sensing [7][8][9][10][11][12], refractive index and gas sensing [15][16][17], dengue virus detection [18], pressure sensing [12,19,20], aqueous environment [21] and biosensing (proteins, avidins, BSA, DNA, etc.) applications [22][23][24][25][26][27][28][29].…”
Section: Introductionmentioning
confidence: 99%