Specific Distribution Behavior of a Ternary Mixture of Solvents Fed into Bent and Wound Microchannels in Microchips

Nishiyama, Kei; Murata, Masaru; Hashimoto, Masahiko; Tsukagoshi, Kazuhiko

doi:10.2116/analsci.29.1003

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…[18][19][20] Also, TRDP appeared in even bent-and wound-microchannels. 34 However, the inner wall materials influenced the stability of the outer phase in the capillary tube.…”

Section: ·1 Visualization Of Trdpmentioning

confidence: 99%

Fundamental Research and Application of the Specific Fluidic Behavior of Mixed Solvents in a Microspace

Tsukagoshi

2014

ANAL. SCI.

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The author herein reviews a specific microfluidic behavior exhibited by mixed-solvent solutions in a microspace, coined as the tube radial distribution phenomenon (TRDP). The specific fluidic behavior was observed in the following solution systems: ternary water-hydrophilic/hydrophobic organic solvents, water-surfactant, water-ionic liquid, and fluorous/ organic solvents. When the mixed homogeneous solutions were delivered into a microspace under certain conditions, the solvent molecules were radially distributed in the microspace, generating inner and outer phases with a kinetic liquid-liquid interface. The TRDP was fundamentally evaluated by fluorescence microscopy, phase diagrams construction, and the elution behaviors of solutes in a capillary tube.

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“…[18][19][20] Also, TRDP appeared in even bent-and wound-microchannels. 34 However, the inner wall materials influenced the stability of the outer phase in the capillary tube.…”

Section: ·1 Visualization Of Trdpmentioning

confidence: 99%

Fundamental Research and Application of the Specific Fluidic Behavior of Mixed Solvents in a Microspace

Tsukagoshi

2014

ANAL. SCI.

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Phase-separation multiphase flow: preliminary application to analytical chemistry

Tsukagoshi

2023

ANAL. SCI.

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A two-phase separation mixed solution can undergo phase separation from one phase to two phases (i.e., upper and lower phases) in a batch vessel in response to changes in temperature and/or pressure. This phase separation is reversible. When the mixed solution undergoes a phase change while being fed into a microspace region, a dynamic liquid–liquid interface is formed, leading to a multiphase structure. This flow is called a phase-separation multiphase flow. Annular flow in a microspace, which is one such phase-separation multiphase flow, is interesting and has been applied to chromatography, extraction, reaction fields, and mixing. Here, research papers related to phase-separation multiphase flows—ranging from the discovery of the phenomenon to basic and technical research from the viewpoint of analytical science—are reviewed. In addition, the development of a new separation mode in a high-performance liquid chromatography system based on phase-separation multiphase flow is introduced. Graphical abstract

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Discovery of Phase-separated Multiphase Flows and Attempts at Academic and Technical Systematization

Tsukagoshi

2022

Bunseki kagaku

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Specific Distribution Behavior of a Ternary Mixture of Solvents Fed into Bent and Wound Microchannels in Microchips

Cited by 3 publications

References 18 publications

Fundamental Research and Application of the Specific Fluidic Behavior of Mixed Solvents in a Microspace

Fundamental Research and Application of the Specific Fluidic Behavior of Mixed Solvents in a Microspace

Phase-separation multiphase flow: preliminary application to analytical chemistry

Discovery of Phase-separated Multiphase Flows and Attempts at Academic and Technical Systematization

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