Specific electroencephalogram features in the very early phases of sporadic Creutzfeldt–Jakob disease

Matsubayashi, Taiki; Akaza, Miho; Hayashi, Yuichi; Hamaguchi, Tetsuya; Satoh, Katsuya; Kosami, Koki; Ae, Ryusuke; Kitamoto, Tetsuyuki; Yamada, Masahito; Shimohata, Takayoshi; Yokota, Takanori; Sanjo, Nobuo

doi:10.1016/j.jns.2022.120265

Cited by 1 publication

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mundlamurri et al reported that in the early stage of sCJD, patients' EEGs can be normal or non-specifically abnormal ( 35 ). In very early phases (1.67 months after onset and before the emergence of generalized PSWC) of sCJD, the predominant findings of EEG can be (1) lateralized periodic discharges (LPDs), (2) central sagittal sporadic epileptiform discharges (CSSEDs), and (3) focal epileptiform discharges ( 38 ). It is suggested that the early presence of the PSWC pattern has a prognostic value because these patients have significantly lower average survival time ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Two clusters of Creutzfeldt–Jakob disease cases within 1 year in West Michigan

et al. 2023

View full text Add to dashboard Cite

BackgroundCreutzfeldt–Jakob disease (CJD) is a rare, rapidly progressive, and uniformly fatal neurodegenerative disease. The reported incidence of CJD is 1 to 2 per million people worldwide annually, with fewer than 1,000 cases in the United States per year. In this study, we report a unique case series on temporo-spatial clusters of CJD cases in West Michigan.MethodsA total of five CJD cases consisting of two temporal clusters were seen from July 2021 to June 2022 at Corewell Health West hospitals. All patients had brain MRI, EEG, and CSF tests. Four patients underwent autopsies.ResultsAll patients' MRIs showed characteristic CJD patterns. Four patients had positive CJD panels in CSF. One patient had typical CJD EEG findings. Four patients were confirmed as sporadic CJD by autopsy. All patients died within 3 months after CJD was suspected.DiscussionAll patients lived within a 90-mile radius of Grand Rapids, MI, and two lived in the same county. West Michigan has a population of 1.6 million people, and the four counties where five patients lived have a combined population of 395,104, indicating CJD's new case rate of 3.1 and 12.5 per million people, respectively. Corewell Health is one of the three major healthcare systems in West Michigan. The actual incidence of CJD in West Michigan is likely even higher. This dense temporal and spatial cluster of CJD cases poses a serious public health challenge and warrants urgent investigation.

show abstract

Section: Discussionmentioning

confidence: 99%