Specific high-performance liquid chromatographic assay with ultraviolet detection for the determination of 1-(2-chloroethyl)-3-sarcosinamide-1-nitrosourea in plasma

Supko, Jeffrey G.; Phillips, L.; Malspeis, Louis

doi:10.1016/0378-4347(95)00430-0

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…The stabilities of the stock solutions of STZ, BCNU (c = 1 × 10 -3 mol l -1 ) and CCNU (c = 2 × 10 -4 mol l -1 ) in water were monitored for 30 days by measuring the absorbance at λ = 230 nm, where the absorption maximum of the N-nitroso chromophore appears 40 . While CCNU degrades very fast, for STZ the absorbance decreases by ca.…”

Section: Spectrophotometric Studies On Stz Bcnu and Ccnu Stabilitymentioning

confidence: 99%

Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes

Pecková

Vrzalová

Bencko

et al. 2009

Collect. Czech. Chem. Commun.

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Dedicated to the memory of Professor Jaroslav Heyrovský on the occasion of the 50th anniversary of the Nobel Prize for polarography.A hanging mercury drop electrode and a mercury meniscus modified silver solid amalgam electrode were used as electroanalytical sensors for voltammetric determination of antineoplastic drugs carmustine, lomustine and streptozotocin containing reducible N-nitroso groups. On the example of carmustine it was shown that its one-step reduction proceeds at substantially more negative potentials at amalgam electrode as compared with mercury electrode. Both electrodes offer satisfactory repeatability of current response (relative standard deviations < 5%) using DC voltammetry and differential pulse voltammetry. The achieved limits of determination lie mostly in the 10 -7 mol l -1 concentration range. The mentioned voltammetric methods were applied to determination of carmustine and lomustine in pharmaceutical formulations. Further, the mercury meniscus modified silver solid amalgam electrode was employed in a "wall-jet" amperometric detection cell in the determination of carmustine by flow injection analysis. Under optimized conditions (run electrolyte BrittonRobinson buffer of pH 7.0; flow rate 5.5 ml min -1 ; detection potential -1.5 V; injection volume 0.02 ml) the limit of quantitation 7.1 × 10 -6 mol l -1 was achieved.

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Section: Spectrophotometric Studies On Stz Bcnu and Ccnu Stabilitymentioning

confidence: 99%

Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes

Pecková

Vrzalová

Bencko

et al. 2009

Collect. Czech. Chem. Commun.

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Transient cerebral hypoperfusion enhances intraarterial carmustine deposition into brain tissue

Joshi

Wang²,

Etu³

et al. 2007

J Neurooncol

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We hypothesized that bolus injections of lipid soluble chemotherapeutic drugs during transient cerebral hypoperfusion could significantly boost regional drug delivery. In the first two groups of New Zealand White rabbits we measured brain tissue carmustine concentrations after intravenous infusion, intraarterial infusion with normal perfusion, and after intraarterial injections during transient cerebral hypoperfusion. In the third group of animals we assessed the safety of the technique by assessing electroencephalographic changes for 6 h after flow arrest carmustine administration and subsequent histological examination. The brain tissue carmustine concentrations were fivefold to sevenfold higher when the drug was injected during cerebral hypoperfusion compared to a conventional intracarotid infusion (68.4 +/- 24.5 vs. 14.2 +/- 8.3 microg/g, n = 5 each, respectively, P < 0.0001). The brain tissue carmustine concentrations (y) were a linear function of the bolus dose (x) injected during cerebral hypoperfusion, y = 10.4 x x - 21 (R = 0.84, P < 0.001). Stable EEGs were recorded several hours after flow arrest carmustine exposure and histological examinations did not reveal any gross evidence of cerebral injury. Transient cerebral hypoperfusion during intraarterial bolus injection of carmustine significantly increases drug delivery. Clinical techniques that decrease CBF, such as, transient arterial occlusion by balloon tipped catheters, hyperventilation, hypothermia, induced hypotension, or transient circulatory arrest, could enhance intraarterial drug delivery to the brain. We believe that the mechanisms for improved drug delivery is the decrease in drug dilution by reduced or absent blood flow, decreased protein binding and a longer time for high concentrations of free drugs to transit through the blood brain barrier.

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Separation methods for alkylating antineoplastic compounds

Paci

Rieutord

Brion

et al. 2001

Journal of Chromatography B: Biomedical Sciences and Applicatio

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Specific high-performance liquid chromatographic assay with ultraviolet detection for the determination of 1-(2-chloroethyl)-3-sarcosinamide-1-nitrosourea in plasma

Cited by 6 publications

References 27 publications

Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes

Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes

Transient cerebral hypoperfusion enhances intraarterial carmustine deposition into brain tissue

Separation methods for alkylating antineoplastic compounds

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