2021
DOI: 10.3389/fimmu.2021.575519
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Specific Host Signatures for the Detection of Tuberculosis Infection in Children in a Low TB Incidence Country

Abstract: Diagnosis of tuberculosis (TB) in children remains challenging due to unspecific clinical presentation and low bacillary load. In low TB incidence countries, most cases are diagnosed by a contact screening strategy after exposure to an index TB case. Due to the severity of TB in young children, the priority is to determine whether a child is infected or not, whereas differential diagnosis between active TB (aTB) and latent TB constitutes a second step. In Belgium, a low TB incidence country, we prospectively i… Show more

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