Specific immune responses in workers exposed to benzene

Dimitrova, Nelia D.; Kostadinova, R.; Marinova, S.; Popov, Todor A.; Panev, Teodor

doi:10.1016/j.intimp.2005.04.012

Cited by 15 publications

(9 citation statements)

References 10 publications

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“…Gasoline immunotoxicity may indeed be influenced by additive immunotoxins, particularly when present at a high concentration or upon prolonged exposure. This concept is supported in a study by Uzma et al [169] who observed significant decreases in Ig levels, cluster of differentiation 4 (CD4) T cells and the CD4 + /CD8 + ratio among gasoline station workers exposed to benzene, which is known for its immunotoxic effects [175][176][177], including suppression of the components and function of the immune system, such as suppression of Ig production and activities of B-and T-lymphocytes in both acute and chronic epidemiological studies [140,178,179]. Increased markers of oxidative stress (ROS and serum MDA), as well as decreased antioxidant enzymes (GSH and total superoxide dismutase (T-SOD)), have been observed in exposed individuals as compared with controls, suggesting the role of oxidative stress in the pathogenesis of the immunotoxicity.…”

Section: Dermatologic Effectsmentioning

confidence: 77%

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Ekpenyong

Asuquo

2017

Int J Occup Med Environ Health

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The impact of health and environmental hazards, associated with the constituents of gasoline, on occupationally exposed workers has been recorded over the past few decades. However, the scientific literature on their pathogenic potential remains incomplete, which could affect the current understanding of the associated health risks. This review provides current information based on recently improved research techniques to evaluate gasoline toxicity profiles for humans. Our current knowledge provides insight into the intricate mechanism of gasoline-induced adverse effects, including the formation of reactive metabolites via bio-activation and subsequent generation of reactive oxygen species (ROS) and oxidative stress, which are involved in multiple mechanisms that are central to the aetiology of gasoline-induced toxicity. These mechanisms include covalent binding to deoxyribonucleic acid (DNA), leading to oxidative damage, tumor-suppression gene activity, and activation of pro-oncogenes. Furthermore, it results in induction of autoimmunity and local inflammatory responses, disruption of multiple neurotransmitters and immune cell function, derangement of various enzyme activities (e.g., sodiumpotassium adenosine triphosphate (Na + /K + /ATPase) activity, cytochrome P450 (CYP450), nitric oxide synthase (NOS), antioxidant enzyme activities, etc.), conjugation of bile, and non-specific cell membrane interaction, leading to damage of the membrane lipid bilayer and proteins. Available data suggests that exposure to gasoline or gasoline constituents have the potential to cause different types of illnesses. The data highlights the need to maintain safety measures via suitable research, medical surveillance, regulatory control, life style modification, early detection, and intervention to minimize exposure and manage suspected cases. They also present novel opportunities to design and develop effective therapeutic strategies against gasoline-induced detrimental effects. Int J Occup Med Environ Health 2017;30(1):1-26

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Section: Dermatologic Effectsmentioning

confidence: 77%

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Ekpenyong

Asuquo

2017

Int J Occup Med Environ Health

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“…These effects include reduced serum immunoglobulins [72,[80][81][82], an anti-benzene antibody response [83] and reduced complement levels [84].…”

Section: Hematotoxicity Caused By Chronic Benzene Exposure -Bone Marrmentioning

confidence: 99%

Effects Of Benzene on Human Hematopoiesis

Kirkeleit¹,

Riise²,

Gjertsen³

et al. 2008

TOHJ

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Benzene, an aromatic hydrocarbon that is a natural component of crude oil and natural gas, is toxic to the blood and blood-forming organs. Epidemiological studies have established an association between benzene exposure and acute myeloid leukemia, and increasing evidence also indicates a possible association between benzene and multiple myeloma. A specific benzene-associated myelodysplastic syndrome has also been suggested. Chronic hematotoxic effects of benzene exposure, including reduced lymphocyte, neutrophil and platelet counts in peripheral blood, have been detected at occupational exposure below a level that had previously been considered not to cause any health effects. Whether these abnormalities represent bone marrow damage and/or initial events in the development of a true neoplastic disease is not known. Together with a reported nonlinear relationship between benzene exposure and the level of various metabolites, favoring production of biologically reactive quinones at exposure below 1 part per million, these observations suggest that benzene even at low exposure levels may contribute to the risk of acute myeloid leukemia or myelodysplastic syndrome, especially among genetically susceptible individuals.

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“…It is clear that exposure to toxic substances has adverse effects on the immune response, and in such circumstances, the proportion of NK cells or their cytotoxic capacity may be affected [15][16][17][18][19]. Although such exposure has mainly been related to occupational activities, to date no attention has been paid to the effects of chronic exposure to toxics on the NK cell activating receptors.…”

Section: Introductionmentioning

confidence: 99%