Specific inflammatory profile in each pregnancy complication: A comparative study

Brien, Marie-Ève; Boufaied, Inès; Bernard, Nathalie; Forest, Jean‐Claude; Giguère, Yves; Girard, Sylvie

doi:10.1111/aji.13316

Cited by 31 publications

(12 citation statements)

References 43 publications

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“…It is important to point out that there is not an international standardization in the techniques to report harmonized results either. However, some other groups reported similar cytokine concentrations to our study values (19,(39)(40)(41)(42)(43)(44)(45)(46).…”

Section: Inflammatory Profile and Osasupporting

confidence: 89%

Influence of Obstructive Sleep Apnea on Systemic Inflammation in Pregnancy

et al. 2021

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Background: Obstructive sleep apnea (OSA) is prevalent in pregnancy and it is associated with adverse pregnancy-related outcomes such as gestational diabetes, pre-eclampsia, and low birth weight. Maternal systemic inflammation is proposed to be one of the main intermediate mechanisms. However, the effects of OSA on systemic inflammation are unknown in normal pregnancy.Methods: Women in the 3rd trimester underwent hospital polysomnography to evaluate whether OSA increases systemic inflammation in normal pregnancy and its potential association with adverse fetal outcomes. OSA was defined as an apnea–hypopnea index (AHI) of ≥ 5 h−1. Plasma cytokines levels (TNF-α, IL-1β, IL-6, IL-8, and IL-10) were determined by multiple immunoassays.Results: We included 11 patients with OSA and 22 women with AHI < 5 h−1, who were homogeneous in age, and body mass index (BMI). Women with OSA had significant higher levels of TNF-α, IL-1β, IL-8, and IL-10. We found significant correlations between AHI during REM and TNF-α (r = 0.40), IL-1β (r = 0.36), IL-6 (r = 0.52), IL-8 (r = 0.43), between obstructive apnea index and TNF-α (r = 0.46) and between AHI and IL-1β (r = 0.43). We also found that CT90% was related to IL-8 (r = 0.37). There were no significant differences in neonatal characteristics; however, we found inverse correlations between TNF-α and IL-8 with birth weight (both r = −0.48), while IL-8 showed a significant inverse relationship with neonatal gestational age (r = −0.48).Conclusions: OSA in our normal pregnancy population was associated with higher systemic inflammation, which was related to obstructive events, especially during REM sleep. Moreover, systemic inflammation was inversely correlated with neonatal birth weight and age.

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Section: Inflammatory Profile and Osasupporting

confidence: 89%

Influence of Obstructive Sleep Apnea on Systemic Inflammation in Pregnancy

et al. 2021

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“…For comparison, in Study II CXCL10 did not significantly differ between groups of PTL, PPROM, antenatal controls and controls in labour at term, neither analysed by multiplex bead assay nor by PEA. Elevated levels of CXCL10 have previously been associated with preeclampsia [218][219][220] , in accordance with the inflammatory properties of CXCL10. Regarding PTB, previous studies have not demonstrated clear associations with levels of CXCL10 220,221 although CXCL10 has been found to be increased in inflammatory conditions of the placenta 222 which might precede PTB.…”

Section: Associations Between the Oxylipins 910-dihode 1112-dihetre 8-hete And Preterm Birthmentioning

confidence: 63%

“…Elevated levels of CXCL10 have previously been associated with preeclampsia [218][219][220] , in accordance with the inflammatory properties of CXCL10. Regarding PTB, previous studies have not demonstrated clear associations with levels of CXCL10 220,221 although CXCL10 has been found to be increased in inflammatory conditions of the placenta 222 which might precede PTB.…”

Section: Associations Between the Oxylipins 910-dihode 1112-dihetre 8-hete And Preterm Birthmentioning

confidence: 63%

Prediction of Spontaneous Preterm Birth : Clinical and Immunological Aspects

Svenvik

2021

Linköping University Medical Dissertations

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Background: Preterm birth (PTB), defined as birth before 37 weeks of gestation, accounts for most neonatal death and morbidity. Accurate prediction is a pre-requisite for the prevention and proper management of PTB. However, methods for prediction are unsatisfactory, although sonographic cervical length has a moderate predictive value. For clinical utility, adding a biomarker could increase the predictive accuracy. The immune system has an important regulatory role during pregnancy. Thus, presumptive predictive biomarkers may be searched for among immune-related molecules, such as cytokines, chemokines and other inflammation-associated mediators.The aims of this thesis were to identify clinical risk factors and immunological prediction markers for PTB, both in women at increased risk of PTB because of preterm labour (PTL) or preterm prelabour rupture of the membranes (PPROM), and in asymptomatic women in early pregnancy. An additional aim was to explore immune reaction patterns in PTL and PPROM compared to normal pregnancy. Material and methods:In a retrospective registry study, including 20,643 women who delivered during a five-year period, risk factors for Apgar score <7 at five minutes and risk factors for PTB <32 weeks were investigated using univariate and multivariate logistic regression. Furthermore, in a multi-centre mixed case-control and prospective cohort study of women with PTL <34 weeks of gestation (n=80), PPROM (n=40), as well as antenatal controls (n=44) and controls in labour at term (n=40), plasma levels of cytokines and chemokines representing different types of immune responses were analysed with a multiplex bead assay. In addition, an extended protein analysis exploring 92 inflammation-associated plasma proteins using proximity extension assay (PEA) was performed, as well as analysis of 67 different oxylipins by liquid chromatography coupled to tandem mass spectrometry. Finally, the PEA technique was used also to explore plasma proteins in a case-control study including 46 women with PTB and 46 women with normal pregnancies and delivery at term. Results and conclusions:A number of partly preventable clinical risk factors for PTB <32 weeks were identified, for example smoking (odds ratio (OR) 1.61 (95% confidence interval (CI) 1.07-2.41)); preeclampsia )); and multiple gestation (OR 15 (95% CI 10-24)). The most evident risk factor for low Apgar scores was PTB; the more preterm the higher the risk. This provides important information for health care professionals, and offers motivations for preventive strategies regarding smoking cessation.

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“…Together with an overall WAT dysfunction [ 8 ], inflammation and oxidative stress are considered some of obesity’s key mechanisms. Obesity-related pregnancy complications are associated with inflammatory and oxidative activities as well [ 15 , 16 ]. Inhibiting these processes in WAT could therefore prevent short-term and persistent damage to mother and child.…”

Section: Introductionmentioning

confidence: 99%

Metformin Prevents Key Mechanisms of Obesity-Related Complications in Visceral White Adipose Tissue of Obese Pregnant Mice

et al. 2022

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With the gaining prevalence of obesity, related risks during pregnancy are rising. Inflammation and oxidative stress are considered key mechanisms arising in white adipose tissue (WAT) sparking obesity-associated complications and diseases. The established anti-diabetic drug metformin reduces both on a systemic level, but only little is known about such effects on WAT. Because inhibiting these mechanisms in WAT might prevent obesity-related adverse effects, we investigated metformin treatment during pregnancy using a mouse model of diet-induced maternal obesity. After mating, obese mice were randomised to metformin administration. On gestational day G15.5, phenotypic data were collected and perigonadal WAT (pgWAT) morphology and proteome were examined. Metformin treatment reduced weight gain and visceral fat accumulation. We detected downregulation of perilipin-1 as a correlate and observed indications of recovering respiratory capacity and adipocyte metabolism under metformin treatment. By regulating four newly discovered potential adipokines (alpha-1 antitrypsin, Apoa4, Lrg1 and Selenbp1), metformin could mediate anti-diabetic, anti-inflammatory and oxidative stress-modulating effects on local and systemic levels. Our study provides an insight into obesity-specific proteome alterations and shows novel modulating effects of metformin in pgWAT of obese dams. Accordingly, metformin therapy appears suitable to prevent some of obesity’s key mechanisms in WAT.

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Specific inflammatory profile in each pregnancy complication: A comparative study

Cited by 31 publications

References 43 publications

Influence of Obstructive Sleep Apnea on Systemic Inflammation in Pregnancy

Influence of Obstructive Sleep Apnea on Systemic Inflammation in Pregnancy

Prediction of Spontaneous Preterm Birth : Clinical and Immunological Aspects

Metformin Prevents Key Mechanisms of Obesity-Related Complications in Visceral White Adipose Tissue of Obese Pregnant Mice

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