Specific Insulin-Like Growth Factor (IGF) I- and II-Binding Sites on Rat Granulosa Cells: Relation to IGF Action*

Davoren, J. B.; Kasson, Barry G.; Li, Choh Hao; Hsueh, Aaron J. W.

doi:10.1210/endo-119-5-2155

Cited by 132 publications

(57 citation statements)

References 37 publications

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“…The IGF-system plays an important role in follicle growth and development [104]. Besides a direct effect, IGF-1 together with insulin indirectly stimulates follicular development through upregulation of the LH-receptor on granulosa cells [105]. Therefore, low systemic IGF-1 concentrations early post partum could contribute to anovulation and subsequent development of cystic follicles as shown by Zulu et al [24].…”

Section: Predisposing Factors For Cofmentioning

confidence: 99%

Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review

2006

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-Cystic ovarian follicles (COF) are an important ovarian dysfunction and a major cause of reproductive failure in dairy cattle. Due to the complexity of the disorder and the heterogeneity of the clinical signs, a clear definition is lacking. A follicle becomes cystic when it fails to ovulate and persists on the ovary. Despite an abundance of literature on the subject, the exact pathogenesis of COF is unclear. It is generally accepted that disruption of the hypothalamo-pituitary-gonadal axis, by endogenous and/or exogenous factors, causes cyst formation. Secretion of GnRH/LH from the hypothalamus-pituitary is aberrant, which is attributed to insensitivity of the hypothalamus-pituitary to the positive feedback effect of oestrogens. In addition, several factors can influence GnRH/LH release at the hypothalamo-pituitary level. At the ovarian level, cellular and molecular changes in the growing follicle may contribute to anovulation and cyst formation, but studying follicular changes prior to cyst formation remains extremely difficult. Differences in receptor expression between COF and dominant follicles may be an indication of the pathways involved in cyst formation. The genotypic and phenotypic link of COF with milk yield may be attributed to negative energy balance and the associated metabolic and hormonal adaptations. Altered metabolite and hormone concentrations may influence follicle growth and cyst development, both at the level of the hypothalamus-pituitary and the ovarian level.cystic ovarian follicles / pathogenesis / hypothalamus-pituitary / ovary / negative energy balance

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Section: Predisposing Factors For Cofmentioning

confidence: 99%

Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review

2006

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“…Both types of receptors have been demonstrated in the various cells of the ovary, including CL membrane [6,24,77]. The IGFR-I binding capacity at the granulosa cell is enhanced by follicle stimulating hormone (FSH) and is also estrogen dependent [2,90].…”

Section: Endocrine Effects Of Igf-i On Reproductive Functionmentioning

confidence: 99%

“…It is also a potent in vitro stimulator of the release of progesterone in cultures of bovine luteal cells or intact tissues [30,51,76]. In the steroidogenic pathway IGFs have been shown to stimulate the aromatase system [3,24]. IGF-I also increases the sensitivity of follicular cells to FSH and LH [80].…”

Section: Endocrine Effects Of Igf-i On Reproductive Functionmentioning

confidence: 99%

Insulin-Like Growth Factor-I as a Possible Hormonal Mediator of Nutritional Regulation of Reproduction in Cattle

Zulu

Nakao

Sawamukai

2002

The Journal of Veterinary Medical Science

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ABSTRACT. The current review aims to establish insulin-like growth factor-1 (IGF-I) as the factor that signals nutritional status to the reproductive axis, and show that assessment of IGF-I in blood early postpartum during the negative energy balance (NEB) period could be used to predict both nutritional and reproductive status in dairy cattle. The review also explores the effect of nutritional status on circulating IGF-I concentrations and the endocrine role of IGF-I on the reproductive axis. IGF-I plays an important role in gonadotropininduced folliculogenesis, ovarian steroidogenesis and corpus luteum (CL) function. It also modulates pituitary and hypothalamus function. IGF-I clearly has an endocrine role on the reproductive axis. Severe under nutrition significantly reduces plasma IGF-I concentrations. During the critical period of NEB in high yielding dairy cattle early postpartum, IGF-I concentrations are low in blood and its levels are positively correlated to energy status and reproductive function during this period. Changes in circulating IGF-I immediately postpartum may help predict both nutritional and reproductive status in dairy cattle. IGF-I is therefore one of the long sought factors that signal nutritional status to the reproductive axis.

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“…IGFs as well as IGFBPs are produced by ovarian granulosa cells (4,5,8). IGF-I acts synergistically with gonadotropins in stimulating a variety of granulosa cell functions, including estrogen and progesterone production and the formation of LH receptors (1,9,10). Furthermore, rat granulosa cells possess specific IGF type I receptors (10).…”

Section: Introductionmentioning

confidence: 99%

Interactions between insulin-like growth factor-I (IGF-I) and the renin-angiotensin system in follicular growth and ovulation.

Yoshimura¹,

Aoki²,

Sueoka³

et al. 1996

J. Clin. Invest.

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The interactions between insulin-like growth factor-I (IGF-I) and the renin-angiotensin system (RAS) in follicular growth and ovulation were studied with the use of an isolated perfused rabbit ovary preparation. Ovulation failed to occur in either control ovaries or the experimental ovaries perfused with IGF-I in a concentration of 1, 10, or 100 ng/ml in the absence of gonadotropin. Exposure to IGF-I stimulated the secretion rate of angiotensin II-like immunoreactivity (Ang II-IR) in perfused rabbit ovaries in a dose-dependent manner. The percent increase in follicle diameter in ovaries perfused with IGF-I for 12 h was significantly correlated with the secretion rate of Ang II-IR at 12 h after exposure to IGF-I. The addition of IGFBP-3 to the perfusate did not induce ovulation in the absence of gonadotropin, but exposure to IGFBP-3 inhibited hCG-induced ovulation in a dosedependent manner. In addition, IGFBP-3 significantly reduced the ovarian secretion rate of Ang II-IR and prostaglandins stimulated by hCG administration. Intrafollicular plasminogen activator (PA) activity significantly increased within 4 h after exposure to 100 ng/ml of IGF-I, compared with that in control ovaries perfused with medium alone. The concomitant addition of IGFBP-3 to the perfusate significantly reduced the IGF-I-stimulated PA activity in the preovulatory follicles at 4, 6, and 8 h after exposure to IGF-I. However, IGFBP-3 alone affected neither the ovarian secretion rate of Ang II-IR nor intrafollicular PA activity. Exposure to streptokinase, an exogenous PA, in vitro stimulated both follicular growth and the intrafollicular Ang II-IR content. In conclusion, IGF-I enhances both ovarian Ang II production and follicular development by stimulating intrafollicular PA activity. ( J. Clin. Invest. 1996. 98:308-316.)

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Specific Insulin-Like Growth Factor (IGF) I- and II-Binding Sites on Rat Granulosa Cells: Relation to IGF Action*

Cited by 132 publications

References 37 publications

Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review

Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review

Insulin-Like Growth Factor-I as a Possible Hormonal Mediator of Nutritional Regulation of Reproduction in Cattle

Interactions between insulin-like growth factor-I (IGF-I) and the renin-angiotensin system in follicular growth and ovulation.

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