Specific oral tolerance induction in paediatric patients with persistent egg allergy

Fuentes‐Aparicio, Victoria; Alvarez-Perea, Alberto; Infante, Sonsoles; Zapatero, L.; D’Oleo, A.; Alonso-Lebrero, Elena

doi:10.1016/j.aller.2012.02.007

Cited by 57 publications

(78 citation statements)

References 16 publications

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“…In a randomized clinical trial, comparing the efficacy of OIT and elimination diet in the treatment of children with egg allergy, among 40 patients in the OIT group, 1 was withdrawn from the trial because of EoE development [56] .…”

Section: Oit and Eosinophilic Esophagitismentioning

confidence: 99%

Oral and Sublingual Immunotherapy: Potential Causes for Eosinophilic Gastrointestinal Disorders?

Babaie

Mesdaghi

Nishino

et al. 2017

Int Arch Allergy Immunol

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Food allergy is a common health problem worldwide, with increasing prevalence during recent decades. The only approved treatments for food allergy are food avoidance and administration of emergency medications in case of accidental exposure, which negatively affects patients' quality of life, so new treatments are highly desirable. Different food immunotherapy modalities have recently been used, with variable success rates in the induction of desensitization and tolerance, and different numbers and types of adverse reactions. Adverse reactions, especially intolerable gastrointestinal symptoms, are the most important causes of immunotherapy withdrawal. Eosinophilic esophagitis has been reported as a complication of milk, egg, and peanut oral immunotherapies and sublingual immunotherapy for respiratory allergies, but not for food allergies. Eosinophilic gastritis and eosinophilic colitis also rarely happened following egg and milk oral immunotherapies. The patients undergoing oral and sublingual immunotherapies should be closely followed up for a long time, and those with gastrointestinal symptoms should be evaluated by endoscopy of the gastrointestinal tract. These complications are usually reversible after early diagnosis and stopping the immunotherapy protocol.

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Section: Oit and Eosinophilic Esophagitismentioning

confidence: 99%

Oral and Sublingual Immunotherapy: Potential Causes for Eosinophilic Gastrointestinal Disorders?

Babaie

Mesdaghi

Nishino

et al. 2017

Int Arch Allergy Immunol

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show abstract

“…Other trials of egg, milk, or peanut OIT have reported lower rates of reactions during dosing (25-45 %), with generally mild reactions limited to oral or pharyngeal symptoms [8•, 9, 11, 13••, 15•]. However, a number of [22][23][24][25][26]. Lucendo and colleagues performed a systematic review with meta-analysis and estimated the prevalence at 2.7 % [27].…”

Section: Oral Immunotherapymentioning

confidence: 99%

An Examination of Clinical and Immunologic Outcomes in Food Allergen Immunotherapy by Route of Administration

Chiang

Berin

2015

Curr Allergy Asthma Rep

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Allergen immunotherapy for the treatment of food allergy has been a subject of intensive study within the last 10 years. After an unsuccessful attempt with subcutaneous immunotherapy for peanut allergy, other routes with varying degrees of safety and efficacy have been tested for peanut, milk, and egg allergies. In this review, we summarize the results to date with oral immunotherapy, sublingual immunotherapy, and epicutaneous immunotherapy for the treatment of food allergy. While results of immunotherapy trials are promising, increases in efficacy are commonly associated with an increased side effect profile. There is a need for additional research beginning at the preclinical level to develop safe and effective treatments for food allergy.

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“…5 After 10 weeks, the patient experienced vomiting and facial erythema after the ingestion of 1 g of powdered pasteurized egg (one tenth of egg). The active substance was replaced with cooked egg (omelet) to continue with the protocol.…”

mentioning

confidence: 99%

“…5 Children who obtained desensitization to cooked eggs did not necessarily reach complete desensitization to raw egg white. 6 However, according to our experience, 54% of children who completed oral desensitization treatment with cooked egg had good tolerance to raw egg white.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Allergy reaction mediated by Gal d 4 (lysozyme) after the induction of tolerance with egg

Infante¹,

López-Matas²,

Carnés³

et al. 2014

Annals of Allergy, Asthma & Immunology

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Specific oral tolerance induction in paediatric patients with persistent egg allergy

Abstract: Our SOTI protocol is a safe, effective treatment for food allergy and of reasonable duration, confirming that tolerance can be induced in children who have not achieved it spontaneously.

Cited by 57 publications

References 16 publications

Oral and Sublingual Immunotherapy: Potential Causes for Eosinophilic Gastrointestinal Disorders?

Oral and Sublingual Immunotherapy: Potential Causes for Eosinophilic Gastrointestinal Disorders?

An Examination of Clinical and Immunologic Outcomes in Food Allergen Immunotherapy by Route of Administration

Allergy reaction mediated by Gal d 4 (lysozyme) after the induction of tolerance with egg

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