2004
DOI: 10.1016/j.cell.2004.11.005
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Specific Polyunsaturated Fatty Acids Drive TRPV-Dependent Sensory Signaling In Vivo

Abstract: by the fat (fatty acid desaturase) and elo (fatty acid and Jennifer L. Watts 4, * elongation) genes. A gas chromatography (GC)-based 1 Neuroscience Graduate Program genetic screen led to the identification of the fat and elo 2 HHMI and Department of Anatomy mutations, which disrupt the synthesis of long chain 513 Parnassus PUFAs from dietary precursors (Figure 1A) (Watts and

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Cited by 165 publications
(164 citation statements)
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“…fat-4 fat-1 mutants, which do not produce AA(20:4n-6) and n-3 PUFAs such as EPA(20:5n-3), were viable and fertile ( Figure 1A; Watts and Browse, 2002;Kahn-Kirby et al, 2004), but they exhibited slow growth at 15°C ( Figure 1B). Dietary supplementation with 25 M AA or EPA led to incorporation of these PUFAs into the phospholipid fractions of fat-4 fat-1 mutants ( Figure 1C), and it rescued the growth defects of this strain ( Figure 1B).…”
Section: Identification Of Genes Involved In the Incorporation Of Exomentioning
confidence: 99%
“…fat-4 fat-1 mutants, which do not produce AA(20:4n-6) and n-3 PUFAs such as EPA(20:5n-3), were viable and fertile ( Figure 1A; Watts and Browse, 2002;Kahn-Kirby et al, 2004), but they exhibited slow growth at 15°C ( Figure 1B). Dietary supplementation with 25 M AA or EPA led to incorporation of these PUFAs into the phospholipid fractions of fat-4 fat-1 mutants ( Figure 1C), and it rescued the growth defects of this strain ( Figure 1B).…”
Section: Identification Of Genes Involved In the Incorporation Of Exomentioning
confidence: 99%
“…Presumably, males and hermaphrodites also produce signals to attract or repel each other, but these cues and the relevant sensory neurons are unknown [3,4]. As "...behavior is messy" (with apologies to [110]), the development of technologies for imaging neuronal activity in single neuron types in vivo in response to an applied stimulus [111][112][113][114][115] may allow for more precise functional mapping of chemicals to sensory neuron types.…”
Section: Mapping Chemicals To Chemosensory Neuronsmentioning
confidence: 99%
“…Thus, in the absence of TAX-2/4 function, these neurons fail to respond to any odorants. However, in a subset of additional neuron types, primary chemosensory signal transduction is likely mediated via the OSM-9 and OCR-2 TRPV channels, which may be gated by polyunsaturated fatty acids (PUFAs) or their derivatives [63,113,144] (Fig. 2b).…”
Section: The Molecules For Taste and Smellmentioning
confidence: 99%
“…[20] These mutants show a number of defects which are rescued by dietary supplementation of C20 and C18 PUFAs, including smaller brood size, alterations in the defecation cycle, and defects in chemotaxis. [20,21] These findings are exciting, because the nematodes amenability to genetic manipulation and the wealth of knowledge concerning its physiology make it an excellent model of lipid signaling. Thus the nematode may have implications for the study of such signaling pathways in mammalian disease models.…”
Section: Introductionmentioning
confidence: 99%