Specific requirements for n‐3 and n‐6 long‐chain polyunsaturated fatty acids for preterm and term infantš

Makrides, Maria; Gibson, Robert A.

doi:10.1002/1438-9312(200106)103:6<373::aid-ejlt373>3.0.co;2-#

Cited by 3 publications

(3 citation statements)

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“…The endogenous conversion of LNA in infants may not be sufficient to support their needs for n‐3 LCPUFA. During the last few decades there has been an extensive research in order to determine whether there is a special dietary need for preformed DHA (Makrides & Gibson, 2001). 22:5n‐6 (osborn acid) is suggested as a useful marker of the DHA‐status (Hornstra, 2000).…”

Section: Discussionmentioning

confidence: 99%

The composition of polyunsaturated fatty acids in erythrocytes of lactating mothers and their infants

Jørgensen

Nielsen²,

Michaelsen³

et al. 2005

Maternal & Child Nutrition

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Long-chain polyunsaturated fatty acids (LCPUFA) in breastmilk, specifically docosahexaenoic acid (DHA), are important for infant brain development. Accretion of DHA in the infant brain is dependent on DHA-status, intake and metabolism. The aim of this study was to describe changes in maternal and infant erythrocyte (RBC) DHA-status during the first four months of lactation. We examined 17 mothers and their term infants at 1, 2 and 4 months of age. Milk samples and RBC from the mothers and infants were obtained and analysed for fatty acid composition. Comparative analysis of the results showed that the content of DHA in maternal RBC-phosphatidylcholine (PE) decreased over the four month period and this was not accompanied by a decrease in DHA in infant RBC-PE (P = 0.005). The ratio of n-6 PUFA to n-3 PUFA increased over time in maternal RBC-PE, but not in infant RBC-PE (P < 0.001). The level of 22:5n-6 and the ratio of LCPUFA to precursor PUFAs in infant RBC was higher than in maternal RBC phospholipids. (P = and P < 0.001 respectively). We found a decrease in the level of LCPUFA in milk, specifically AA. However, we did not observe a significant decrease in milk DHA, which may have been due to two outliers. These results indicate better DHA-status and a higher n-3/n-6 PUFA in RBC of infants than in mothers. Whether these differences reflect preferential n-3 PUFA transfer via breastmilk or differences in PUFA-metabolism and utilization remains to be shown.

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Section: Discussionmentioning

confidence: 99%

The composition of polyunsaturated fatty acids in erythrocytes of lactating mothers and their infants

Jørgensen

Nielsen²,

Michaelsen³

et al. 2005

Maternal & Child Nutrition

View full text Add to dashboard Cite

show abstract

“…And 18:3n-3 is able to fulfill the n-3 FA requirement of term infants, at least in the sense that it prevents apparent deficiency symptoms. It is currently under debate whether dietary 18:3n-3 optimally fulfills the n-3 FA requirement in infants (6,14) and possibly pregnant and lactating women (15), or whether they might benefit from an additional intake of preformed 22:6n-3.…”

mentioning

confidence: 99%

“…In recent reviews on the n-3 requirement of human infants, 22:6n-3 is called a conditionally essential (25,26) or an optional nutrient (14). This seems awkward when 22:6n-3 is the primary reason for n-3 FA essentiality.…”

mentioning

confidence: 99%