Specific Suppressor T‐Cells Immune to Antigens of the H‐2 Complex: Receptors, Clonal Structure, Genetic Restriction and Antigenic Markers

Brondz, B. D.; Abronina, I. F.; Zaiceva, M. B.; Filatov, Alexander; Chervonsky, Alexander V.

doi:10.1111/j.1600-065x.1984.tb00494.x

Cited by 17 publications

(3 citation statements)

References 104 publications

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“…In a study in mice, Brondz et al (1984) made observations similar to those described above including the existence of an unspecific suppiession. In humans, Zeevi et al (1982) using cloned alloactivated T-lymphocytes found suppressor cells with specificity for determinants other than HLA-DR, DQ, or DP.…”

Section: Discussionmentioning

confidence: 52%

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HLA‐DP related suppression of mixed lymphocyte reaction with alloactivated lymphocytes

et al. 1986

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We studied the influence of HLA class I and class II antigens on the suppression of the MLR induced by primed lymphocytes (PLs) alloactivated in vitro. The suppression of 14 different PLs of 83 MLRs was analyzed. The PLs were primed against (i) HLA‐DP (SB) (ii) HLA‐DR/DQ or (iii) both HLA‐DP and DR/ DQ. The suppression was analyzed with special reference to the sharing of HLA‐antigens between (i) the stimulator in the MLR and (ii) the stimulator generating the PL. HLA‐DP and HLA‐DR/DQ antigens were equally capable of generating suppressor cells. When these cells were added to MLRs, the specific stimulators induced the strongest suppression (74%), while allogeic cells sharing class II antigens induced a slightly weaker suppression (66%). The suppression related to HLA‐DP (60%) was almost identical to that related to HLA‐DR/DQ (59%). The HLA‐A, B, C related suppression was of the same magnitude (58%). The unspecific suppression (40%), i.e. no relation to known HLA‐antigens, was significantly lower than the class II related suppression, but not significantly lower than the class I related suppression. The suppression of the MLR did not seem to be caused by cytotoxic cells, consumption of lymphokines, nor changes in the kinetics of the MLR. Thus, HLA‐DP antigens can ‐ like DR/DQ antigens ‐ induce PLs with the ability to suppress the MLR in an HLA‐class II (DP or DR/DQ) related, and possibly a class I related, as well as an unspecific fashion.

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Section: Discussionmentioning

confidence: 52%

“…Family studies, including an HLA-B/DR recombinant indicated that this suppression was specific for the HLA-DR antigens present on the surface of the stimulating cells (Sasportes et al 1978). In mice, various gene products of the MHC are capable of inducing suppressor cells and of re-actin4 with them (Brondz et al 1984).…”

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confidence: 99%

HLA‐DP related suppression of mixed lymphocyte reaction with alloactivated lymphocytes

et al. 1986

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“…Via these soluble mediators, helper T cells carry out the central role of immune regulation, that is, differentiating B cells into antibody-producing cells (8)(9)(10) and generating cytotoxic T lymphocytes (CTL) from precursor cells (5,15,29,35,40). In contrast, CD8+ suppressor T cells M.J. TANABE downregulate the immune response by means of suppressor factors acting on lb cells (3,7,34). It is well known that non-T cells can also regulate the immune response.…”

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confidence: 99%

Prethymic Nylon Wool‐Passed Bone Marrow Cells, Substituting for Helper T Cells, Can Augment the Generation of Cytotoxic T Lymphocytes from Their Precursors

Tanabe

1991

Microbiology and Immunology

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Effect of Lead on Macrophage Function

Kowolenko

Tracy

Mudzinski

et al. 1988

Journal of Leukocyte Biology

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Lead (Pb) has been shown to alter various parameters of immune function such as host resistance and antibody formation. In addition, various heavy metals have been implicated as inducers of autoimmunity. In these experiments, macrophages, isolated from the peritoneal cavity of mice exposed to various doses of lead in vivo as well as cells exposed in vitro were tested for the following immunologic parameters: phagocytosis, antigen presentation, interleukin 1 production, and their ability to stimulate the autologous mixed lymphocyte reaction (AMLR). The results obtained indicate that Pb appears to alter the ability of macrophages to present antigen by enhancing the AMLR while having no effect on phagocytosis or IL-1 production. These data suggest that Pb may interfere with antigen-specific interactions between macrophages and T cells.

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Specific Suppressor T‐Cells Immune to Antigens of the H‐2 Complex: Receptors, Clonal Structure, Genetic Restriction and Antigenic Markers

Cited by 17 publications

References 104 publications

HLA‐DP related suppression of mixed lymphocyte reaction with alloactivated lymphocytes

HLA‐DP related suppression of mixed lymphocyte reaction with alloactivated lymphocytes

Prethymic Nylon Wool‐Passed Bone Marrow Cells, Substituting for Helper T Cells, Can Augment the Generation of Cytotoxic T Lymphocytes from Their Precursors

Effect of Lead on Macrophage Function

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