Speckle-tracking-derived strain and strain-rate analysis: a technique for the evaluation of early alterations in right ventricle systolic function in patients with systemic sclerosis and normal pulmonary artery pressure

Matias, Carla; Isla, Leopoldo Pérez de; Vasconcelos, Mariana; Almerı́a, Carlos; Rodrigo, José Luis; Serra, Viviana; Zamorano, José

doi:10.2459/jcm.0b013e32831af028

Cited by 50 publications

(26 citation statements)

References 24 publications

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“…The introduction of the new STE method has enabled a more precise assessment of LV function [24] and enables regional and global assessment of the left ventricle. Previous studies have indicated that 2D STE is more sensitive than conventional echocardiography for detecting subclinical ventricular dysfunction in various clinical disorders [25,26]. Erdogan et al [27] reported that the GLS values decreased considerably in PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

Demirelli¹,

Değirmenci²,

Ermis³

et al. 2015

Biomol Biomed

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Polycystic ovary syndrome (PCOS) is characterized by hormonal and metabolic abnormalities and is thought to increase a risk for cardiovascular diseases. In this study we use speckle tracking echocardiography (STE) to evaluate left ventricular (LV) dysfunction in the early period of the disease. We enrolled 31 patients with PCOS and 32 healthy volunteers as a control group. The participants' ages ranged between 18 and 40 years. PCOS was diagnosed according to the Rotterdam criteria. LV strain (LS) and strain rate (SR) were evaluated using apical two-chamber (2C), three-chamber (3C), and four-chamber (4C) imaging. Global LS and SR were calculated as average of three apical views. The waist-to-hip ratio, homeostasis model assessment-insulin resistance (HOMA-IR), and fasting insulin and triglyceride levels were higher in the PCOS group than in the controls (p = 0.001, p = 0.001, p = 0.001, and p = 0.005, respectively). In the PCOS group, the mitral A wave, deceleration time (DT), and isovolumetric relaxation time (IVRT) were significantly higher than in the controls (all p < 0.05). The LV global longitudinal strain (GLS) and global longitudinal SR systolic (GLSRS) were significantly lower in the PCOS patient group (both p = 0.001). There were strong negative correlations between GLS and both fasting insulin (r = −0.64) and DT (r = -0.62) (both p < 0.05). The study demonstrated that PCOS patients had decreased LV function using STE. Therefore, STE imaging appears to be useful for the early detection of subclinical LV dysfunction in patients with PCOS.

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Section: Discussionmentioning

confidence: 99%

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

Demirelli¹,

Değirmenci²,

Ermis³

et al. 2015

Biomol Biomed

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“…RV LPSS was measured with speckle-tracking strain echocardiography. 11,12,14 Clinical and echocardiographic data were prospectively collected in the departmental Cardiology Information System (EPD-Vision, Leiden University Medical Center, Leiden, the Netherlands) and the echocardiography database and were retrospectively analyzed. All patients were followed-up for the occurrence of all-cause mortality.…”

Section: Patient Population and Data Collectionmentioning

confidence: 99%

Prognostic Value of Right Ventricular Longitudinal Peak Systolic Strain in Patients With Pulmonary Hypertension

Haeck

Scherptong

Marsan

et al. 2012

Circ: Cardiovascular Imaging

217

137

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Background-Right ventricular (RV) function is an important prognostic marker in patients with pulmonary hypertension.The present evaluation assessed the prognostic value of RV longitudinal peak systolic strain (LPSS) in patients with pulmonary hypertension. Methods and Results-A total of 150 patients with pulmonary hypertension of different etiologies (mean age, 59±15 years; 37.3% male) were evaluated. RV fractional area change and tricuspid annular plane systolic excursion index were evaluated with 2-dimensional echocardiography. RV LPSS was assessed with speckle-tracking echocardiography. The patient population was categorized according to a RV LPSS value of -19%. Among several clinical and echocardiographic parameters, the significant determinants of all-cause mortality were evaluated. There were no significant differences in age, sex, pulmonary hypertension cause and left ventricular ejection fraction between patients with RV LPSS <−19% and patients with RV LPSS ≥−19%. However, patients with RV LPSS ≥−19% had significantly worse New York Heart Association functional class (2.7±0.6 versus 2.3±0.8; P=0.003) and lower tricuspid annular plane systolic excursion (16±4 mm versus 18±3 mm; P<0.001) than their counterparts. During a median follow-up of 2.6 years, 37 patients died. RV LPSS was a significant determinant of all-cause mortality (HR, 3.40; 95% CI, P=0.02). Conclusions-In patients with pulmonary hypertension, RV LPSS is significantly associated with all-cause mortality. RV LPSS may be a valuable parameter for risk stratification of these patients. Future studies are needed to confirm these results in the pulmonary hypertension subgroups. (Circ Cardiovasc Imaging. 2012;5:628-636.)

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“…Real-time three-dimensional echocardiography, for example, may provide quantitation of RV end-diastolic volume and other focused assessments of the RV. Likewise, two-dimensional speckletracking image analysis can assess myocardial deformation to inform about the extent of RV remodeling and strain; this may prove particularly useful in detecting subclinical PVD (which presumably predates PH) in the setting of subjects who are at risk of PH due to a coexistent condition, such as scleroderma (38).…”

Section: Novel Methods To Detect Pvd Before Pah Is Presentmentioning

confidence: 99%

Pulmonary Hypertension: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases

Austin

Kawut²,

Gladwin³

2014

Annals ATS

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Pulmonary vascular dysfunction (PVD) precedes the onset of clinical signs and symptoms of pulmonary arterial hypertension (PAH). PAH is defined by the elevation of pulmonary arterial pressure, which often progresses to right ventricular (RV) dysfunction and failure. PAH affects subjects of all ages, and is associated with diverse medical conditions, most of which are rare. Several factors pose immediate challenges to the development of strategies for primary prevention of PAH, including: (1) the idiopathic or primary form of the disease is extremely rare, limiting screening practicality; (2) methods for the detection of preclinical PVD are currently not established; (3) the understanding of determinants of pulmonary vascular growth, structure, and function in normal and PAH states is insufficient; (4) relatively small numbers of "at-risk" subjects are available for long-term studies to accurately assess disease development; and (5) preventative therapies for PVD are lacking. Despite these limitations, leveraging known at-risk patient populations for study, as well as growing progress across multiple disciplines, ranging from systems biology to advanced and more sensitive functional imaging modalities, may facilitate the opportunity to significantly improve primary prevention research and implementation over the next decade.

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Speckle-tracking-derived strain and strain-rate analysis: a technique for the evaluation of early alterations in right ventricle systolic function in patients with systemic sclerosis and normal pulmonary artery pressure

Cited by 50 publications

References 24 publications

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

Prognostic Value of Right Ventricular Longitudinal Peak Systolic Strain in Patients With Pulmonary Hypertension

Pulmonary Hypertension: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases

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