SPECT and PET MPI: The future has arrived but it is unevenly distributed

Higgins, Andrew; Jaber, Wael A.

doi:10.1007/s12350-019-02005-2

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Different pathophysiological mechanisms of HF are assessed with different radiopharmaceuticals (Table 1). The most commonly utilized cardiac PET tracers include molecules to assess myocardial blood flow (MBF), such as 13 N-Ammonia ([ 13 Evaluation of increased metabolism (e.g., inflammation) [2,[22][23][24] and myocardial viability Originally, PET imaging has been established in the evaluation of coronary disease since it offers myocardial viability assessment and quantification of regional MBF [25,26]. Beyond this role, PET imaging has been shown to also provide valuable information in patients with valvular heart disease, sarcoidosis, amyloidosis, and other forms of cardiomyopathy [27].…”

Section: Tracermentioning

confidence: 99%

Positron Emission Tomography in Heart Failure: From Pathophysiology to Clinical Application

Tersalvi

Beltrani

Grübler

et al. 2023

JCDD

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Imaging modalities are increasingly being used to evaluate the underlying pathophysiology of heart failure. Positron emission tomography (PET) is a non-invasive imaging technique that uses radioactive tracers to visualize and measure biological processes in vivo. PET imaging of the heart uses different radiopharmaceuticals to provide information on myocardial metabolism, perfusion, inflammation, fibrosis, and sympathetic nervous system activity, which are all important contributors to the development and progression of heart failure. This narrative review provides an overview of the use of PET imaging in heart failure, highlighting the different PET tracers and modalities, and discussing fields of present and future clinical application.

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Section: Tracermentioning

confidence: 99%

Positron Emission Tomography in Heart Failure: From Pathophysiology to Clinical Application

Tersalvi

Beltrani

Grübler

et al. 2023

JCDD

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“…Though single-photon emissioncomputed tomography (SPECT) remains the most common nuclear modality for coronary ischemia assessment, its functional specificity has declined over time due to impaired spatial resolution in patients with a higher body mass index [18]. This barrier may be mitigated by the use of computed tomography attenuation correction with SPECT or, instead, use of positron emission tomography (PET), which in addition to superior diagnostic accuracy over SPECT also offers myocardial viability assessment and quantification of regional myocardial blood flow [19,20]. The use of quantitative myocar-dial blood flow analysis has also shown promise in surveillance for cardiac allograft vasculopathy in patients after orthotopic heart transplantation [21].…”

Section: Key Pointsmentioning

confidence: 99%

The role of multimodality imaging in patients with heart failure with reduced and preserved ejection fraction

Hassan

Higgins

2022

Current Opinion in Cardiology

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Purpose of reviewThe burden of clinical heart failure, both heart failure with a reduced ejection fraction (HFrEF) and with a preserved ejection fraction (HFpEF), continues to increase both nationally and globally. This review summarizes the expanding role of multimodality imaging techniques in the evaluation and management these patients. Recent findingsEchocardiographic assessment for heart failure continues to expand and should include a robust hemodynamic and strain assessment. Nuclear techniques have also continued to evolve and advances including computed tomography attenuation correction for single photon emission-computed tomography positron-emission tomography increase diagnostic accuracy as well as provide information such as myocardial blood flow and viability assessment. Computed tomography imaging, already well established in the assessment of coronary and valvular disease, has increasing utility in the characterization of myopathy, and cardiac magnetic resonance imaging (MRI) continues to expand its role in tissue characterization to a wider breadth of diseases, including right ventricular cardiomyopathy and left ventricle noncompaction.

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PET/CT Myocardial Perfusion Imaging Acquisition and Processing: Ten Tips and Tricks to Help You Succeed

et al. 2021

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SPECT and PET MPI: The future has arrived but it is unevenly distributed

Cited by 5 publications

References 13 publications

Positron Emission Tomography in Heart Failure: From Pathophysiology to Clinical Application

Positron Emission Tomography in Heart Failure: From Pathophysiology to Clinical Application

The role of multimodality imaging in patients with heart failure with reduced and preserved ejection fraction

PET/CT Myocardial Perfusion Imaging Acquisition and Processing: Ten Tips and Tricks to Help You Succeed

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