Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation

Martać, Ljiljana; Grbic, G.; Keković, Goran; Podgorac, Jelena; Ćulić, Milka; Sekulić, Slobodan; Lalosevic, Djordje; Čapo, Ivan

doi:10.2298/abs1001009m

Cited by 2 publications

(2 citation statements)

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“…These changes imply that desynchronized activity strives to establish a balance in terms of increasing slow-wave/sporadic components. Particularly, an increase in the delta range is an indicator of neurotoxicity, while change in the delta/theta relation is a criterion of intoxication [18]. The FD of electrocortical activity during neurotoxicity has a lower value [19].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous cerebellar activity and its role in neurotoxicity

2017

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Introduction. In performed experiments, the parietal electrocortical activity of the cerebral cortex and the activity of the cerebellar cortex were simultaneously recorded. The main purpose was to compare their spontaneous activity, as the recording was conducted during anesthesia. Material and Methods. We used 2-3 months old rats weighing 200 - 350 g. Two groups of rats with same characteristics were made. The first group of 15 rats (control group) was recorded under anesthesia and there was a change in spectral power in accordance with frequency ranges. The second group of 30 rats was recorded under the same experimental conditions, but the rats were treated intraperitoneally by aluminium chloride hexahydrate solution or with 1.5% solution of aluminium chloride hexahydrate per os. Discussion. Changes in spontaneous activity of the cerebellum during aluminium intoxication were compared with control values. It was shown that lesion and neurotoxicity during stable anesthesia led to desynchronization of the cerebellar activity. This is described by the change in fractal dimension of cerebellar electrocortical activity. The assumption is that the inhibition caused by anesthetic is compensated during aluminium intoxication. Conclusion. The cerebellum plays a role in compensation through changes in spontaneous activity. This response involves an increase in the value of fractal dimension of cerebellar electrocortical activity which is reduced in neurotoxicity. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 175006]

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Section: Discussionmentioning

confidence: 99%

Spontaneous cerebellar activity and its role in neurotoxicity

2017

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“…Alterations of amino acids metabolism in brain are also region specific in response to aluminium exposure [31]. The importance of cerebro-cerebellar connections could be investigated on brain signal processing in young rats (whose mothers were intoxicated by aluminium via drinking water during gestation and lactation period) where we have noticed an extreme predominance of slow ECoG power spectra at the parietal cortical level [28,32]. Early electrophysiological findings under mild aluminium intoxication could be of even greater importance, as characteristic AD morphological changes cannot be found in vivo.…”

Section: Discussionmentioning

confidence: 99%

Fractal dimension values of cerebral and cerebellar activity in rats loaded with aluminium

Keković

Ćulić

Martać

et al. 2010

Med Biol Eng Comput

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Aluminium interferes with a variety of cellular metabolic processes in the mammalian nervous system and its intake might increase a risk of developing Alzheimer's disease (AD). While cerebral involvement even at the early stages of intoxication is well known, the role of cerebellum is underestimated. Our aim was to investigate cerebral and cerebellar electrocortical activity in adult male rats exposed to chronic aluminium treatment by nonlinear analytic tools. The adult rats in an aluminium-treated group were injected by AlCl(3), intraperitoneally (2 mg Al/kg, daily for 4 weeks). Fractal analysis of brain activity was performed off-line using Higuchi's algorithm. The average fractal dimension of electrocortical activity in aluminium-treated animals was lower than the average fractal dimension of electrocortical activity in the control rats, at cerebral but not at cerebellar level. The changes in the stationary and nonlinear properties of time series were more expressed in cerebral electrocortical activity than in cerebellar activity. This can be useful for developing effective diagnostic and therapeutic strategies in neurodegenerative diseases.

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Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation

Cited by 2 publications

References 4 publications

Spontaneous cerebellar activity and its role in neurotoxicity

Spontaneous cerebellar activity and its role in neurotoxicity

Fractal dimension values of cerebral and cerebellar activity in rats loaded with aluminium

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