“…The FPSs (mass median diameter) used in the design were 91, 211, and 450 lm, respectively. 28 The average particle diameters of ibuprofen used in the design were 71, 95, and 154 lm, respectively, and the average concentration was varied at five levels; 16,18,20,22, and 24 (%w/w), respectively. Properties for different filler sizes and the manufacturing methods are presented in Table I.…”