Spectral characterization, cyclic voltammetry, morphology, biological activities and DNA cleaving studies of amino acid Schiff base metal(II) complexes

Neelakantan, M.A.; Rusalraj, F.; Dharmaraja, Jeyaprakash; Johnsonraja, Samuelraj; Jeyakumar, Thayalaraj Christopher; Pillai, M. Sankaranarayana

doi:10.1016/j.saa.2008.06.008

Cited by 168 publications

(57 citation statements)

References 36 publications

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“…Stiff, yellow oil (0.22 g, yield 65% 4 were solved by direct methods and refined by full-matrix least-squares on F 2 using all data [10]. All non-hydrog en atoms were refined with anisotropic atomic displacemen t parameters and the hydrogen atoms bonded to carbon were inserted at calculated positions using a riding model.…”

Section: General Synthesis Of Zinc(ii) Complexesmentioning

confidence: 99%

“…In recent years, metal complexes comprising Schiff base ligands have been shown to exhibit significant anticancer, antiviral and antimicrobial activity [1][2][3][4]. Commercially available 1-(3-aminopropyl)imidazole (Apim) (Fig.…”

Section: Introductionmentioning

confidence: 99%

“…Commercially available 1-(3-aminopropyl)imidazole (Apim) (Fig. 1) has recently been complexed to the Ag(I) ion and the structurally characterised complexes, [Ag(Apim)]ClO 4 [5] and [Ag(Apim)](9-aca)ÁH 2 O (9-acaH = 9-anthracen ecarboxylic acid) [6], exhibit high antimicro bia l act ivi ties , in vit ro . In add iti on , me tal com ple xes com pri sin g Schiff base ligands derived from Apim have also attracted attention.…”

Section: Introductionmentioning

confidence: 99%

“…H and 13 C NMR (d ppm; J Hz) spectra were recorded on a BrukerAvan ce 300 MHz NMR spectromete r using saturated d 6 -DMSO solutions with Me 4 Si reference, unless indicated otherwise, with resolutions of 0.18 Hz and 0.01 ppm, respectively . Infrared spectra (cm À1 ) were recorded as KBr discs using a Perkin Elmer System2000 FT-IR spectromete r. UV-vis spectra were run on a Unicam UV 540 spectromete r. Melting point analyses were carried out using a Stewart Scientific SMP 1 melting point apparatus and are uncorrected.…”

mentioning

confidence: 99%

“…The interpretation of mass spectra was made with the help of the program, ''Agilent Masshunter Workstation Software ''. Magnetic susceptibi lity measurements were carried out at room temperature using a Johnson Matthey Magnetic Susceptibility Balance with [HgCo(SCN) 4 ] as reference. Microanal ytical data were carried out using an Electron Corporation Thermo FlashEA 1112 Series analyser.…”

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confidence: 99%

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Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities

McGinley¹,

McCann²,

Ni³

et al. 2013

Polyhedron

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a b s t r a c t 1-(3-Aminopropyl)imidazole (Apim) reacts with salicylaldeh yde and a selection of imidazole aldehydes and the resulting Schiff base ligands readily coordinate to Zn(II), Cu(II) and Ag(I) centres. X-ray crystal structures were obtained for two of the free ligands and also the Ag(I) complex of the Apim-salicylaldehyde ligand. Encouragingly, all of free ligands and most of their metal complexes are relatively non-toxic, in vivo , towards Galleria mellonella . Although the free ligands and the Cu(II) and Zn(II) complexes are inactive, in vitro , against a selection of microbial pathogens, most of the Ag(I) complexes exhibit moderate anti-bacterial activity and good anti-fungal activity.

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Section: General Synthesis Of Zinc(ii) Complexesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities

McGinley¹,

McCann²,

Ni³

et al. 2013

Polyhedron

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Different Routes of Synthesis

Singh

Gogoi

Barman

2023

Schiff Base Metal Complexes

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Homo‐ and heteropolynuclear copper(II) complexes containing a new diimine–dioxime ligand and 1,10‐phenanthroline: synthesis, characterization, solvent‐extraction studies, catalase‐like functions and DNA cleavage abilities

Dede

Özmen

Karipçin

et al. 2009

Applied Organom Chemis

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A series of homo-, heterodinuclear and homotrinuclear copper(II) complexes containing a new Schiff base ligand and 1,10-phenanthroline were synthesized. Based on results of elemental analyses, FTIR, 1 H-and 13 C-NMR spectra, conductivity measurements and magnetic susceptibility measurements, the complexes had general compositions {[Cu(L)(H 2 O)M(phen) 2 ](ClO 4 ) 2 [M = Cu(II), Mn(II), Co(II)]} and {[Cu 3 (L) 2 (H 2 O) 2 ](ClO 4 ) 2 }. The metal : L : phen ratio is 2 : 1 : 2 for the dinuclear copper(II) complexes and the metal : L ratio was 3 : 2 for the trinuclear copper(II) complex. The liquid-liquid extraction of various transition metal cations [Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Pb(II), Cd(II), Hg(II)] from the aqueous phase to the organic phase was carried out using the diimine-dioxime ligand. It was concluded that the ligand can effectively be used in solvent extraction of copper(II) from the aqueous phase to the organic phase. Furthermore, catalytic activitiy of the complexes for the disproportionation of hydrogen peroxide was also investigated in the presence of imidazole. Dinuclear copper(II)-manganese(II) complex has some similarity to manganese catalase in structure and activity. The interaction between these complexes and DNA has also been investigated by agarose gel electrophoresis; we found that the homo-and heterodinuclear copper complexes can cleave supercoiled pBR322 DNA to nicked and linear forms in the presence of H 2 O 2 .

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Spectral characterization, cyclic voltammetry, morphology, biological activities and DNA cleaving studies of amino acid Schiff base metal(II) complexes

Cited by 168 publications

References 36 publications

Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities

Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities

Different Routes of Synthesis

Homo‐ and heteropolynuclear copper(II) complexes containing a new diimine–dioxime ligand and 1,10‐phenanthroline: synthesis, characterization, solvent‐extraction studies, catalase‐like functions and DNA cleavage abilities

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