Spectral Domain Optical Coherence Tomography Documentation of Macular Pseudohole Evolution and Spontaneous Resolution

Walter, Scott D.; Flynn, Harry W.

doi:10.1097/icb.0000000000000268

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Gass first reported the spontaneous improvement in iERMs in 1976 in eight patients with normal or near-normal initial BCVA 1. While only a minority of patients (<10%) with iERM may expect spontaneous improvement in BCVA, this possibility must also be weighed against the risks of surgery 18–20…”

Section: Discussionmentioning

confidence: 99%

<p>The Clinical Course of Patients with Idiopathic Epiretinal Membranes and Good Visual Acuity Managed Without Surgery</p>

Damasceno

Crane

et al. 2019

OPTH

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Background/aimsTo report the clinical course of patients with idiopathic epiretinal membranes (iERMs) and good baseline best-corrected visual acuity (BCVA) managed without surgical treatment.MethodsRetrospective, observational case series of patients with iERMs and 20/50 or better BCVA who did not undergo surgery between January 2014 and December 2017 with a 1-year follow-up. Secondary epiretinal membranes were excluded. iERMs were stratified into two groups: Group I (BCVA 20/30 or better) and Group II (BCVA 20/40 to 20/50). The main outcome measures included baseline and final follow-up BCVA, central macular thickness (CMT) on OCT.ResultsThe study included 174 eyes (145 patients): 139 eyes (79.8%) had typical iERMs and 35 eyes (18%) had LMH. For Group I typical iERMs, the logMAR baseline and final mean BCVA were 0.09 ± 0.1 (Snellen equivalent 20/25) and 0.10 ± 0.1 (20/25+) respectively (p = 0.22). In this group, the baseline and final mean CMT were 335 ± 73µm and 342 ± 78µm, respectively (p = 0.47). For Group II typical iERMs, the logMAR baseline and final mean BCVA were 0.3 ± 0.1 (20/44) and 0.4 ± 0.2 (20/45) respectively (p = 0.31). In this group, the baseline and final mean CMT were 386 ± 95µm and 391 ± 93µm, respectively (p = 0.84).ConclusionThe clinical course of patients with iERM and good baseline BCVA is generally favorable without surgery and includes stable BCVA and OCT measurements after at least one year.

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Section: Discussionmentioning

confidence: 99%

<p>The Clinical Course of Patients with Idiopathic Epiretinal Membranes and Good Visual Acuity Managed Without Surgery</p>

Damasceno

Crane

et al. 2019

OPTH

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“…Since the latter is less photostable as compared to STAR 512 , partial bleaching of the labeled vimentin filaments was observed in the second acquisition (Figure S11b). In both cases, complete color separation in all four channels required the use of spectral unmixing …”

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“…(b) Confocal imaging of living U2OS cells stably expressing a vimentin-HaloTag construct labeled with 3-Halo and live cell-compatible probes MitoTracker Deep Red FM (specific for mitochondria), abberior LIVE 510-tubulin (microtubules), and Hoechst 33342 (DNA). Spectral unmixing of individual channels was performed according to ref . Scale bars: 10 μm.…”

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Photoactivatable Large Stokes Shift Fluorophores for Multicolor Nanoscopy

Likhotkin

Lincoln

Bossi³

et al. 2023

J. Am. Chem. Soc.

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We designed caging-group-free photoactivatable live-cell permeant dyes with red fluorescence emission and ∼100 nm Stokes shifts based on a 1-vinyl-10-silaxanthone imine core structure. The proposed fluorophores undergo byproduct-free one- and two-photon activation, are suitable for multicolor fluorescence microscopy in fixed and living cells, and are compatible with super-resolution techniques such as STED (stimulated emission depletion) and PALM (photoactivated localization microscopy). Use of photoactivatable labels for strain-promoted tetrazine ligation and self-labeling protein tags (HaloTag, SNAP-tag), and duplexing of an imaging channel with another large Stokes shift dye have been demonstrated.

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AgrUNet: A Multi-GPU UNet Based Model for Crops Classification

Miola,

Calore,

Schifano

2024

IEEE Access

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Spectral Domain Optical Coherence Tomography Documentation of Macular Pseudohole Evolution and Spontaneous Resolution

Abstract: Spontaneous epiretinal membrane peeling represents a potential mechanism for visual and anatomical improvement in eyes with MPH. This is the first published observation of MPH resolution documented by spectral domain optical coherence tomography.

Cited by 3 publications

References 14 publications

<p>The Clinical Course of Patients with Idiopathic Epiretinal Membranes and Good Visual Acuity Managed Without Surgery</p>

<p>The Clinical Course of Patients with Idiopathic Epiretinal Membranes and Good Visual Acuity Managed Without Surgery</p>

Photoactivatable Large Stokes Shift Fluorophores for Multicolor Nanoscopy

AgrUNet: A Multi-GPU UNet Based Model for Crops Classification

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