Spectral-Domain Optical Coherence Tomography in Uveitic Macular Edema: Morphological Features and Prognostic Factors

Abstract

Aim: To assess the morphological characteristics of uveitic macular edema studied with Spectralis optical coherence tomography (OCT) and to investigate the correlation between the tomographic features and visual acuity. Methods: 71 eyes of 55 patients underwent examination with Spectralis OCT (Heidelberg Engineering, Germany). Data was correlated with logMAR best-corrected visual acuity (BCVA). Results: Two morphological patterns were observed: cystoid macular edema (CME) in 69% and diffuse macular edema in 31% of eyes. BCVA was 0.2 in CME, 0.1 in diffuse edema (p = 0.008). Foveal thickness was 413.4 ± 212 µm in CME, 311.27 ± 53 µm in diffuse edema (p = 0.03). BVCA was 0.3 in eyes with serous retinal detachment (SRD), 0.2 in eyes without SRD (p = 0.02). BCVA was 0.4 in eyes with inner segment/outer segment (IS/OS) disruption, 0.1 in eyes with integrity of the IS/OS junction (p = 0.01). Conclusions: BCVA is negatively correlated with cystoid pattern, foveal thickening and SRD. Disruption of the IS/OS junction is associated with poor vision in uveitic macular edema.

Longitudinal study of retinal status using optical coherence tomography after acute onset endophthalmitis following cataract surgery

“…These observations suggest that secondary ERM postacute endophthalmitis differed from idiopathic ERM in their increased frequency in ellipsoid band abnormalities and a rapidly increased prevalence over time. The prognostic value of ellipsoid band impairment is unknown in the context of postendophthalmitis ERM, whereas it has been demonstrated for idiopathic15–18 or uveitic ERM 7. In our cohort, ERM was associated with a lower VA at M12 compared with patients presenting normal macular status.…”

Optical coherence tomography imaging in uveitis

“…A negative correlation between central foveal thickness and visual acuity has also been described in other studies [43,45,47,49]. Although DME was found to be associated with poor visual recovery after treatment [50], some studies point to a negative visual outcome in patients with uveitic CME [45,48,51,52]. The presence of serous retinal detachment in eyes with uveitic macular edema has been shown not to worsen the visual prognosis [50,53].…”

Efficacy of Ozurdex implant in recalcitrant diabetic macular edema—a single-center experience

“…Recently, the SD-OCT has been used to study the effect of integrity of the external limiting membrane (ELM) and ellipsoid zone (revised nomenclature for photoreceptor inner segment and outer segment junction) on the final visual acuity [22][23][24]. Available data from few studies suggest that disruption of these layers is associated with poor visual outcome in patients with DME, retinal vein occlusions, and uveitic macular edema [25][26][27][28][29][30]. The time when the retinal structural damage occur to ELM and ellipsoid zone in DME is not clearly known.…”