Spectral-Domain Optical Coherence Tomography Study on Dynamic Changes of Human Tears After Instillation of Artificial Tears

Napoli, Pietro Emanuele; Satta, Giovanni Maria; Coronella, Franco; Fossarello, Maurizio

doi:10.1167/iovs.14-14666

Cited by 31 publications

(27 citation statements)

References 26 publications

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“…Napoli et al. () found similar results with sodium carboxymethylcellulose and phosphosphatidylglycerol, being the residence time higher than baseline for at least 10 min.…”

Section: Discussionmentioning

confidence: 65%

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Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

Carracedo

Pastrana

Serramito

et al. 2018

Acta Ophthalmologica

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Purpose: To evaluate changes in tear meniscus dynamics using optical coherence tomography (OCT) after the instillation of different concentrations of sodium hyaluronate (SH) ophthalmic solutions. Methods: An experimental, double-masked, randomized study was performed. Twenty-three healthy subjects (16 women and seven men; mean age 23.57 AE 2.56 years) participated in this study. About 35 ll of 0.1%, 0.2%, 0.3% SH ophthalmic solutions and saline solution was instilled in a randomly assigned eye. Tear meniscus measurements (height, depth and turbidity) were taken with OCT at 30 seconds and 1, 3, 5, 10 and 20 min after instillation. Subsequently, the Schirmer test and tear break-up time (TBUT) were evaluated. Results: Tear meniscus depth and tear meniscus height showed a significant increase with all solutions compared to basal values: up to 3 min for 0.1% SH, up to 5 min for 0.2% and up to 10 min for 0.3% SH ophthalmic solution. Tear meniscus turbidity was also increased at 30 seconds for 0.1%, 0.2% and 0.3% SH artificial tears (p < 0.05). This increase remained significant for up to 1 min for 0.2% and 0.3% SH solutions (p < 0.05). After 5 min of saline and 0.1% SH instillation, the turbidity was lower than basal values (p < 0.05). There was a significant increase in the TBUT for all solutions after instillation (p < 0.05). No differences between the Schirmer pre-and postinstillation were found (p > 0.05). Finally, the comfort was significantly improved for all ophthalmic solutions (p < 0.05). Conclusion: Sodium hyaluronate (SH) ophthalmic solutions increase residence time in healthy subjects and are positively correlated with its concentration and therefore the viscosity.

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“…Napoli et al. () found similar results with sodium carboxymethylcellulose and phosphosphatidylglycerol, being the residence time higher than baseline for at least 10 min.…”

Section: Discussionmentioning

confidence: 65%

“…; Napoli et al. ). Optical coherence tomography (OCT) is considered a noninvasive and practical method for imaging tear meniscus and a potential diagnostic tool for dry eye syndrome (Ibrahim et al.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

Carracedo

Pastrana

Serramito

et al. 2018

Acta Ophthalmologica

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“…The precorneal TF can also be evaluated by OCT imaging to analyze, in real time and non-invasively, the dynamic changes induced by different artificial tears (ATs). We found that the TF morphological pattern is related to the chemical composition of tear substitutes [42]. We observed a raise in OCT reflectivity when lipid concentration is augmented, and an increase in thickness with the use of water-soluble polymers.…”

Section: Structure and Appearance Of The Tear Filmmentioning

confidence: 68%

Fourier-Domain OCT Imaging of the Ocular Surface and Tear Film Dynamics: A Review of the State of the Art and an Integrative Model of the Tear Behavior during the Inter-Blink Period and Visual Fixation

Napoli

Nioi

Mangoni

et al. 2020

JCM

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In the last few decades, the ocular surface and the tear film have been noninvasively investigated in vivo, in a three-dimensional, high resolution, and real-time mode, by optical coherence tomography (OCT). Recently, OCT technology has made great strides in improving the acquisition speed and image resolution, thus increasing its impact in daily clinical practice and in the research setting. All these results have been achieved because of a transition from traditional time-domain (TD) to Fourier-domain (FD) technology. FD-OCT devices include a spectrometer in the receiver that analyzes the spectrum of reflected light on the retina or ocular surface and transforms it into information about the depth of the structures according to the Fourier principle. In this review, we summarize and provide the state-of-the-art in FD-OCT imaging of the ocular surface system, addressing specific aspects such as tear film dynamics and epithelial changes under physiologic and pathologic conditions. A theory on the dynamic nature of the tear film has been developed to explain the variations within the individual compartments. Moreover, an integrative model of tear film behavior during the inter-blink period and visual fixation is proposed.

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“…14,15 Miscellaneous noninvasive approaches such as confocal microscopy, interferometry, and OCT used to quantify preocular tear film thickness have shown results ranging widely from 3 to 45 mm. [16][17][18] Spectral domain OCT seems to be an objective method for assessing preocular tear film thickness, 19 the average of which in this study was approximately 22 mm. Although it is impossible to accept spectral domain OCT measurements of tear film as the gold standard, they do provide consistent, reliable data.…”

Section: Discussionmentioning

confidence: 78%

Comparison of Corneal Layers and Anterior Sclera in Emmetropic and Myopic Eyes

Pekel

Yağcı

Acer

et al. 2015

Cornea

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Spectral-Domain Optical Coherence Tomography Study on Dynamic Changes of Human Tears After Instillation of Artificial Tears

Cited by 31 publications

References 26 publications

Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

Fourier-Domain OCT Imaging of the Ocular Surface and Tear Film Dynamics: A Review of the State of the Art and an Integrative Model of the Tear Behavior during the Inter-Blink Period and Visual Fixation

Comparison of Corneal Layers and Anterior Sclera in Emmetropic and Myopic Eyes

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