Spectrofluorimetric Method for Estimation of Curcumin in Rat Blood Plasma: Development and Validation

A highly selective nanocomposite based on MIP for curcumin trace levels quantification in food samples and human plasma following optimization by central composite design

“…Various role including antioxidant, anti-inflammatory, antibacterial, antiviral, anti-atherosclerotic, anti-arthriticagent and anticancer activities [16][17][18][19] are logical reasons for its extensive application and encourage researchers to design an accurate approach for preconcentration and quantification of curcumin in low level in complicated matrices. Several methods such as high-performance liquid chromatography [20][21][22], thin layer chromatography [23], UV-Vis spectrophotometry [24], HPTLC [25], 2-D flash liquid chromatography [26] and spectrofluorimetry [27,28] are applied for this regard. HPLC method compared to other techniques benefit from remarks like high reliability and efficiency and selectivity is appropriate for analyzing real samples with complex matrices, while for analytes with extremely low concentration a preliminarily preconcentration help the researchers to reduce the interference correspond to other constituents and simultaneously improve the performance of proposed method [29].…”