Spectrophotometric Determination of Furosemide Drug in Different Formulations using Schiff ’s Bases

Abstract

Simple, accurate and reproducible UV spectrophotometric method was established for the assay of Fourosemide based on the formation of Schiff 's bases coupling with aromatic aldehydes such as benzaldehyde, salicylaldehyde, 2-methoxy benzaldehyde, anisaldehyde, vanilline, 2,3,4-chlorobenzaldehyde, 4-nitro benzaldehyde and dimethylaminobenzaldehyde in presence of sulphuric acid, The optical characteristics such as Beer's law limits, molar absorptivity and Sandell's sensitivity for the methods are given. Regression analysis using the method of least squares was made to evaluate the slope (b), intercept (a) and correlation coefficient (r) and standard error of estimation (SE) for each aldehyde. Determination of furosemide in bulk form and in pharmaceutical formulations were also incorporated.

Use of Green Fluorescent Nano-sensors for the Determination of Furosemide in Biological Samples and Pharmaceutical Preparations

“…(F 0 -F)/F 0 = 0.193C -0.0079 (R 2 = 0.9994) (5) where F is the uorescence intensity of N-CQDs in the presence of studied drug, F 0 is the uorescence intensity of N-CQDs in the absence of FRS, C is the drug concentration in µg/mL. The values of LOD and LOQ proved that the suggested method is su ciently sensitive as summarized in Table 1 The accuracy of the proposed method was con rmed by calculating the mean % recoveries of raw material of FRS.…”

Enhanced diuretic action of furosemide by complexation with β-cyclodextrin in the presence of sodium lauryl sulfate

“…The mixed suspensions were shaken at 100 rpm and 37°C for 72 h in a water bath. The resultant solutions were filtered using a 0.45 µm membrane filter and then analyzed by UV at 272 nm [23].…”

“…The aliquot of 5 mL of the sample was withdrawn at each time point (0, 10, 20, 30, 40, 50, and 60 min) and compensated with new media. The samples were filtered, suitably diluted, and analyzed by UV at 272 nm [23].…”

Instantaneous determination of antihypertensive drugs utilizing TLC: Densitometric methods

“…The literature review shows that FUR was determined in its bulk powder by liquid chromatography (LC) [6] and spectroscopy (Schiff's bases) [6], [7] . The binary mixture of SPIR and FUR was determined by some spectrophotometric methods (variable angle scanning fluorescence spectrophotometry [8], derivative ratio [9] and determined by reversed phase liquid chromatography [5,10] .…”