Spectrophotometric Determination of Zinc in Pharmaceutical and Biological Samples with Di‐2‐pyridyl Ketone Benzoylhydrazone: a Simple, Fast, Accurate and Sensitive Method

Vieira, L. E. M.; Vieira, F.P.; Ávila-Terra, Lúcia Helena S.; Gaubeur, Ivanise; Guekezian, Márcia; Suárez-Iha, Maria Encarnación Vázquez

doi:10.1080/00032710801934841

Cited by 13 publications

(3 citation statements)

References 19 publications

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“…Zn(II) forms a chelate complex with many reagents such as thiosemicarbazones. Some representative examples are benzildithiosemicarbazone [13], di-2-pyridyl ketone salicyloylhydrazone [14], 2,4-dihydroxybenzaldehyde isonicotinoyl hydrazone [15], pyridoxal-4-phenyl-3thiosemicarbazone [16], N-ethyl-3carbazolecarboxaldehyde-3-thiosemicarbazone [17], di-2-pyridyl ketone benzoylhydrazone [18], bis-[2,6-(2′-hydroxy-4′-sulpho-1′-napthylazo)]pyridine disodium salt [19], and 5,7-dibromo-8hydroxyquinoline [20], salicylaldehyde thiosemicarcbazone [21]. In recent years, the complexation of 5-bromosalicylaldehyde thiosemicarbazone (5-BSAT) reagent with some metallic ions has been reported.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Study of a new Complexation between Zn(II) and 5-Bromosalicylaldehyde Thiosemicarbazone and Its Application

Tán

2021

Egypt. J. Chem.

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A new complex of Zn(II) and 5-Bromosalicylaldehyde thiosemicarbazone (5-BSAT) has been studied. In solution, the 5-BSAT reacts with Zn(II) to form a complex with the maximum absorbance at 381 nm. Zn(II) ion forms a 1:1 stoichiometric complex. The stability constant is 4.21x10 5 . The formation of the complex was completed within 20 min at pH 6.8 and VDMF = 2 mL. Beer's law is obeyed over the range from 0.13 mg. L -1 to 0.39 mg. L -1 Zn (II) and the apparent molar absorptivity (ε) is 1.08×10 4 L.mol −1 .cm −1 . The complex has been formulated and characterized by mass spectrometry, FT-IR, 1 H-NMR and 13 C-NMR spectroscopies and IQmol program. The molecular formula of the complex is C8H8O2N3SBrZn. The ligand coordinated as an ONS tridentate dianion through the oxygen atom of the deprotonated phenolic OH-group, the azomethine nitrogen atom and the sulfur atom after deprotonation of the thiosemicarbazide residue in its thiol form. Based on these results, the 5-BSAT reagent was applied to determine zinc in waste water samples and the complex showed an effective antimicrobial activity.

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Section: Introductionmentioning

confidence: 99%

Spectrophotometric Study of a new Complexation between Zn(II) and 5-Bromosalicylaldehyde Thiosemicarbazone and Its Application

Tán

2021

Egypt. J. Chem.

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“…di-2-pyridyl ketone (dpk) and a variety of its hydrazonic derivatives (dpk-h) such as hydrazones, semicarbazones, and thiosemicarbazones (see scheme 1) continue to attract research interest because of their physicochemical properties and applications in many areas including medicine [3-5, 8, 9, 12, 19], sensors [17,18], supramolecular networks [1], catalysis [2], etc. .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic and X-ray crystallographic properties of manganese compounds of keto- and enol-coordinated di-2-pyridyl ketone benzoyl hydrazone (dpkbh). Reactions of [Mn(CO)₅Br] with dpkbh

Conry

2016

Journal of Coordination Chemistry

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To cite this article: Mohammed Bakir & Rebecca Conry (2016): Synthesis, spectroscopic and Xray crystallographic properties of manganese compounds of keto-and enol-coordinated di-2-pyridyl ketone benzoyl hydrazone (dpkbh). Reactions of [Mn(CO) 5 Br] with dpkbh, Journal of Coordination Chemistry, ABSTRACT Reactions between [Mn(CO) 5 Br] and dpkbh in low boiling solvents in air gave fac-[Mn I (CO) 3 (κ 2 -N py ,N im -dpkbh)Br]·H 2 O, [Mn II Br 2 (κ 3 -N py ,N im ,O-dpkbh)], and [Mn II (κ 3 -N py ,N im ,O-dpkbh-H) 2 ]·0.5H 2 O (N im = imine nitrogen and N py = pyridyl nitrogen). Crystallization of fac-[Mn I (CO) 3 (κ 2 -N py ,N im -dpkbh) Br]·H 2 O from dmso or CH 3 CN produced dark red crystals of [Mn II (κ 3 -N py ,N im ,Odpkbh-H) 2 ]·nX (X = dmso, n = 1 and X = H 2 O, n = 0.22). This is in contrast to the reaction of [Re(CO) 5 Cl] with dpkbh in refluxing toluene to form fac-[Re I (CO) 3 (κ 2 -,N py ,N py -dpkbh)Cl] which can be crystallized from CH 3 CN, dmso or dmf to form fac-[Re I (CO) 3 (κ 2 -,N py ,N py -dpkbh)Cl]·nX (X = CH 3 CN, n = 0 and solvate = dmso or dmf, n = 1). Infrared spectral measurements are consistent with keto coordination of dpkbh to Mn(I) in fac-[Mn I (CO) 3 (κ 2 -N py ,N im -dpkbh) Br]·H 2 O and Mn(II) in [Mn II Br 2 (κ 3 -N py ,N im ,O-dpkbh)] plus enol coordination of the amide-deprotonated dpkbh, to the Mn(II) center in [Mn II (κ 3 -N py ,N im ,Odpkbh-H) 2 ]·0.5H 2 O. Electronic absorption spectral measurements in nonaqueous solvents indicate sensitivity of fac-[Mn I (CO) 3 (κ 2 -N py ,N im -dpkbh) Br]·H 2 O and [Mn II (κ 3 -N py ,N im ,O-dpkbh-H) 2 ]·0.5H 2 O to changes in their outershell environments. X-ray crystallographic analyses elucidated the identities of [Mn II Br 2 (κ 3 -N py ,N im ,O-dpkbh)] and [Mn II (κ 3 -N py ,N im ,O-dpkbh-H) 2 ]·nX and divulged weaker coordination of [dpkbh] to Mn(II) in [Mn II Br 2 (κ 3 -N py ,N im ,Odpkbh)] and stronger coordination of [dpkbh-H] − to Mn(II) in [Mn II (κ 3 -N py ,N im ,O-dpkbh-H) 2 ]·0.22H 2 O. Low-temperature X-ray structural analyses were employed to account for the disorder in the structure of [Mn II (κ 3 -N py ,N im ,O-dpkbh-H) 2 ] and the short NH bond distance observed in the structure of [Mn II Br 2 (κ 3 -N py ,N im ,O-dpkbh)]. A PLATON SQUEEZE treatment was invoked to account for the fractional occupancy of lattice water in the structure of [Mn II (κ 3 -N py ,N im ,O-dpkbh-H) 2 ]. ARTICLE HISTORY

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“…16 Because of its beneficial effects for humans, zinc has been included as a constituent of the pharmaceutical formulations available in the market. [17][18][19] Therefore, the determination of its presence in pharmaceutical products is a requirement for assuring quality. This has been done by employing spectrophotometry.…”

Section: Introductionmentioning

confidence: 99%

A LED based photometer for solid phase photometry: zinc determination in pharmaceutical preparation employing a multicommuted flow analysis approach

Dias¹,

Reis²

2012

J. Braz. Chem. Soc.

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Neste trabalho é proposto um fotômetro baseado em LED (diodo emissor de luz) para fotometria em fase sólida. O fotômetro foi desenvolvido para permitir o acoplamento da fonte de radiação (LED) e do fotodetector direto na cela de fluxo, tendo um caminho óptico de 4 mm. A cela de fluxo foi preenchida com material sólido (C 18 ), o qual foi utilizado para imobilizar o reagente cromogênico 1-(2-tiazolilazo)-2-naftol (TAN). A exatidão foi avaliada empregando dados obtidos através da técnica ICP OES (espectrometria de emissão por plasma indutivamente acoplado). Aplicando-se o teste-t pareado não foi observada diferença significativa em nível de confiança de 95%. Outros parâmetros importantes encontrados foram faixa de resposta linear de 0,05 a 0,85 mg L -1 Zn, limite de detecção de 9 µg L -1 Zn (n = 3), desvio padrão de 1,4 % (n = 10), frequência de amostragem de 36 determinações por h, e uma geração de efluente e consumo de reagente de 1,7 mL e 0,03 µg por determinação, respectivamente.In this work, a LED (light emitting diode) based photometer for solid phase photometry is described. The photometer was designed to permit direct coupling of a light source (LED) and a photodiode to a flow cell with an optical pathlength of 4 mm. The flow cell was filled with adsorbing solid phase material (C 18 ), which was used to immobilize the chromogenic reagent 1-(2-thiazolylazo)-2-naphthol (TAN). Aiming to allow accuracy assessment, samples were also analyzed employing ICP OES (inductively coupled plasma optical emission spectrometry) methodology. Applying the paired t-test at the 95% confidence level, no significant difference was observed. Other useful features were also achieved: linear response ranging from 0.05 to 0.85 mg L -1 Zn, limit of detection of 9 µg L -1 Zn (3σ criterion), standard deviation of 1.4% (n = 10), sampling throughput of 36 determinations per h, and a waste generation and reagent consumption of 1.7 mL and of 0.03 µg per determination, respectively.

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Spectrophotometric Determination of Zinc in Pharmaceutical and Biological Samples with Di‐2‐pyridyl Ketone Benzoylhydrazone: a Simple, Fast, Accurate and Sensitive Method

Cited by 13 publications

References 19 publications

Spectrophotometric Study of a new Complexation between Zn(II) and 5-Bromosalicylaldehyde Thiosemicarbazone and Its Application

Spectrophotometric Study of a new Complexation between Zn(II) and 5-Bromosalicylaldehyde Thiosemicarbazone and Its Application

Synthesis, spectroscopic and X-ray crystallographic properties of manganese compounds of keto- and enol-coordinated di-2-pyridyl ketone benzoyl hydrazone (dpkbh). Reactions of [Mn(CO)₅Br] with dpkbh

A LED based photometer for solid phase photometry: zinc determination in pharmaceutical preparation employing a multicommuted flow analysis approach

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Spectrophotometric Determination of Zinc in Pharmaceutical and Biological Samples with Di‐2‐pyridyl Ketone Benzoylhydrazone: a Simple, Fast, Accurate and Sensitive Method

Cited by 13 publications

References 19 publications

Spectrophotometric Study of a new Complexation between Zn(II) and 5-Bromosalicylaldehyde Thiosemicarbazone and Its Application

Spectrophotometric Study of a new Complexation between Zn(II) and 5-Bromosalicylaldehyde Thiosemicarbazone and Its Application

Synthesis, spectroscopic and X-ray crystallographic properties of manganese compounds of keto- and enol-coordinated di-2-pyridyl ketone benzoyl hydrazone (dpkbh). Reactions of [Mn(CO)5Br] with dpkbh

A LED based photometer for solid phase photometry: zinc determination in pharmaceutical preparation employing a multicommuted flow analysis approach

Contact Info

Product

Resources

About

Synthesis, spectroscopic and X-ray crystallographic properties of manganese compounds of keto- and enol-coordinated di-2-pyridyl ketone benzoyl hydrazone (dpkbh). Reactions of [Mn(CO)₅Br] with dpkbh